Can I take Magnesium 5 in one and Progynova together?
Drug interaction guide
Originally published 25 Jan 2026
Erfüllt die Anforderungen des Patienten redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen Sie
- Sprache
- Diskussion
Taking magnesium supplements at the same time as Progynova (estradiol) may slightly reduce how much of the hormone your body absorbs. This could potentially make your hormone replacement therapy (HRT) less effective.
In diesem Artikel:
Lesen Sie unten weiter
Why this happens
Magnesium can bind to certain medications in the digestive tract or change the acidity of the stomach, which can interfere with how well the body absorbs oestrogen.
What you should do
You do not need to stop taking either, but it is best to separate the doses. Take your Progynova at least 2 hours before or 4 to 6 hours after taking your magnesium supplement. If you notice a return of menopause symptoms (like hot flushes), speak to your doctor.
Lesen Sie unten weiter
Important precautions
Blood clots and stroke
This medicine significantly increases your risk of developing blood clots (DVT or pulmonary embolism) and stroke. Seek immediate medical help if you experience painful leg swelling, sudden chest pain, or breathlessness.
Severe kidney impairment
If you have severe kidney disease, you must not take magnesium supplements. Your kidneys may not be able to remove excess magnesium from your blood, which can lead to dangerous levels affecting your heart and breathing.
Brustkrebs
Progynova can stimulate the growth of certain types of breast cancer. You must perform regular breast self-checks and attend all scheduled mammograms while using this treatment.
Food and drink warnings
Grapefruit juice
Grapefruit juice can increase the levels of estradiol in your blood, which may increase the risk of side effects. It is best to avoid large amounts of grapefruit juice while taking this medicine.
Dairy products (Milk, Cheese, Yoghurt)
Calcium-rich foods like dairy can interfere with how your body absorbs magnesium if taken at the same time. Try to space out your magnesium supplement and dairy intake by at least 2 hours.
Alkohol
Regular or excessive alcohol consumption can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective.
Caffeine (Coffee, Tea, Energy drinks)
High intake of caffeine can have a mild diuretic effect, which may increase the excretion of magnesium from the body.
Lesen Sie unten weiter
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Behandlung und Medikamente
Can I take Ashwagandha and Oestrogel pump-pack /actuation together?
Ashwagandha may increase the levels of oestrogen in your body, potentially making the effects of your Oestrogel stronger than intended. It might also interfere with how your body naturally balances hormones.

Behandlung und Medikamente
Can I take Evana heavy period relief and Mefenamic acid together?
Taking these two medicines together significantly increases your risk of serious stomach problems, such as stomach ulcers, bleeding, or irritation of the stomach lining. It can also put extra strain on your kidneys.
Lesen Sie unten weiter
Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
25 Jan 2026 | Ursprünglich veröffentlicht

Fragen, teilen, verbinden.
Stöbern Sie in Diskussionen, stellen Sie Fragen, und tauschen Sie Erfahrungen zu Hunderten von Gesundheitsthemen aus.

Fühlen Sie sich unwohl?
Beurteilen Sie Ihre Symptome online und kostenlos
Melden Sie sich für den Patienten-Newsletter an
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsratschläge – geschrieben, damit Sie sich informiert, sicher und unter Kontrolle fühlen.
Mit Ihrer Anmeldung akzeptieren Sie unsere Datenschutzerklärung. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals weiter.