Can I take Metformin and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
Erfüllt die Anforderungen des Patienten redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen Sie
- Sprache
- Diskussion
Taking metformin and Rybelsus (semaglutide) together can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). You may also experience more stomach-related side effects like nausea or diarrhoea.
In diesem Artikel:
Lesen Sie unten weiter
Why this happens
Both medicines work in different ways to lower blood sugar. Metformin reduces the amount of sugar your liver produces, while Rybelsus helps your body release more insulin when you eat. When used together, their effects are additive, meaning they work together to lower blood sugar more than either would alone.
What you should do
It is very common for these two medicines to be prescribed together. However, you should monitor your blood sugar levels regularly as your doctor advises. Learn to recognise the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy) and always carry a fast-acting sugar source. If you experience severe or persistent stomach upset, speak to your doctor.
Lesen Sie unten weiter
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Behandlung und Medikamente
Can I take Idapamide and Ramipril together?
Taking indapamide and ramipril together can cause your blood pressure to drop too low, especially when you first start the combination. This can make you feel dizzy, lightheaded, or faint. It can also put extra strain on your kidneys.

Behandlung und Medikamente
Can I take Esomeprazole and Magnesium together?
Taking esomeprazole for a long time (usually more than three months) can lower the levels of magnesium in your blood. This can lead to symptoms like tiredness, muscle spasms, or an irregular heartbeat. Additionally, if you take magnesium as an antacid or supplement at the same time as esomeprazole, it might slightly interfere with how well the medicine is absorbed.
Lesen Sie unten weiter
Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
25 Jan 2026 | Ursprünglich veröffentlicht

Fragen, teilen, verbinden.
Stöbern Sie in Diskussionen, stellen Sie Fragen, und tauschen Sie Erfahrungen zu Hunderten von Gesundheitsthemen aus.

Fühlen Sie sich unwohl?
Beurteilen Sie Ihre Symptome online und kostenlos
Melden Sie sich für den Patienten-Newsletter an
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsratschläge – geschrieben, damit Sie sich informiert, sicher und unter Kontrolle fühlen.
Mit Ihrer Anmeldung akzeptieren Sie unsere Datenschutzerklärung. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals weiter.