HRT: Überprüfung von Risiken und Vorteilen

What is HRT?

Hormonersatztherapie (HRT) is a treatment that replaces the hormones that decrease when you're going through menopause, which can ease the symptoms you're having. HRT is given as two hormones, oestrogen and progesterone, if you have a womb (uterus) - and as oestrogen-only if you no longer have a womb.

Professor Anne MacGregor, a member of the British Menopause Society's advisory board, says that perceptions of risk have changed significantly over time as increasingly safer forms of HRT have been developed.

"Women worry about breast cancer but obesity, smoking, and drinking alcohol regularly carry a greater risk of breast cancer than taking HRT," she says.

"Blood clots have been another concern but topical oestrogen as a skin patch, gel, or spray does not increase your risk of blood clots.

"For any individual woman, the risks associated with taking HRT need to be balanced against the benefits, including symptom control, but also long-term protection against Osteoporose, Herz-Kreislauf-Erkrankungen, and vulvovaginal atrophy - thinning and drying of the vulva and vagina."

Does HRT increase risks of breast cancer?

Yes, it does slightly increase your risk, but the benefits of HRT outweigh the risks. The NHS advises that combined HRT is linked with a small increase in the risk of breast cancer, but there is little or no change with oestrogen-only HRT. Your risk depends on how long you use HRT, and this falls after you stop taking HRT.

Does HRT increase risks of endometrial cancer?

If you still have a womb and only take oestrogen-only HRT, this would increase your risk of endometrial cancer. This is why oestrogen-only HRT is never given on its own if you have a womb. Taking combined HRT with the added progesterone protects your womb lining from the effects of oestrogen, and therefore doesn't affect your cancer risk.

Does HRT increase the risk of blood clots?

Yes, from tablets - but not patches. If you have a history of Blutgerinnsel you may not be able to be given HRT. Doctors also advise controlling Bluthochdruck before starting HRT.

Dr Paula Briggs, consultant at Liverpool Women’s NHS Foundation Trust and past-chair of the British Menopause Society (BMS), says doctors may recommend topical HRT to patients with a risk of blood clots: "When we give oestrogen through the skin, it doesn't affect the risk of having a blood clot. So, for a patient who's got a BMI of, say, 30 or more, that patient already has an inherent risk, and you wouldn't want to make that risk any higher by giving oral oestrogen.”

Managing night sweats

Many women have hot flushes and night sweats during the menopause, which can affect your mood and sleep, as well as being uncomfortable in themselves.

Reducing vaginal dryness

During the menopause, you may notice your sex drive falls, and your vagina may get drier. HRT may be able to help you maintain your sex life and reduce the discomfort of these physical changes.

Osteoporose

HRT has also been shown to keep bones strong and prevent osteoporosis, which becomes more common in women after the menopause.

After you've familiarised yourself with the different types of HRT, and the way risks vary between these types, your doctor can tell you what HRT you can be given and what they advise.

Beyond HRT, doctors often recommend diet and lifestyle changes - for example, stopping smoking and cutting back on caffeine, alcohol, and spicy food. Some doctors might recommend non-hormonal medicines to treat hot flushes and night sweats, and some women find self-guided KVT helps with sleep changes during menopause.

Professor MacGregor says that many people who think they cannot take HRT may actually be able to, depending on the type of cancer and the treatment they have had, and most can use vaginal oestrogen.

"For those who can't take HRT, there are plenty of other ways to help their symptoms and long term health, although it is true to say that they don't provide the same all-round benefit of HRT," she says.