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Can I take 1%/2.5% and Doxycycline together?

Drug interaction guide

Using these two treatments together can make your skin significantly more sensitive to sunlight. This increases your risk of developing a painful sunburn, skin rashes, or irritation even with brief exposure to the sun or UV lamps.

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Why this happens

Both benzoyl peroxide (the 2.5% ingredient in your gel) and doxycycline are known to cause 'photosensitivity'. This means they lower your skin's natural defence against UV rays. When used at the same time, this effect is combined, making your skin much more vulnerable to light damage.

You can use these together, but you must be very careful in the sun. Always wear a high-factor sunscreen (SPF 30 or higher), wear protective clothing, and avoid sunbeds or prolonged sun exposure. If you develop a severe rash or painful peeling, stop using the gel and contact your doctor.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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