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Can I take 1.25 and Zinc together?

Drug interaction guide

Taking zinc supplements at the same time as 1.25 (calcitriol) can lead to high levels of calcium in your blood. This can cause symptoms like feeling sick, constipation, or feeling very thirsty. Additionally, high doses of zinc can sometimes interfere with how your body uses vitamin D.

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Why this happens

Calcitriol (1.25-dihydroxyvitamin D3) increases how much calcium your body absorbs from food. Zinc can also influence calcium metabolism. When taken together, they may cause calcium levels to rise too high (hypercalcaemia). Furthermore, zinc and vitamin D share certain pathways in the body, and an excess of one can sometimes affect the balance of the other.

You should speak to your doctor or pharmacist before taking zinc supplements with calcitriol. They may want to monitor your blood calcium levels more closely. If you do take both, it is often best to space them at least 2 hours apart to reduce any direct interference in the gut.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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