Can I take 15 and Hour transdermal together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Combining alcohol with a buprenorphine patch (the active medicine in 15 microgram/hour transdermal patches) can lead to dangerous levels of drowsiness, extreme sleepiness, and breathing difficulties. It can also significantly increase the risk of liver damage.
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Why this happens
Both alcohol and buprenorphine are 'central nervous system depressants', meaning they slow down brain activity and breathing. When used together, their effects are added together, which can cause the body to 'forget' to breathe. Additionally, both substances are processed by the liver, and combining them puts extra strain on this organ.
What you should do
Back to contentsIt is best to avoid alcohol completely while using this patch. Even small amounts of alcohol can increase the risk of severe side effects like fainting or respiratory distress. If you feel unusually sleepy, dizzy, or have trouble breathing, seek medical help immediately.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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