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Can I take 15 and Microgynon together?

Drug interaction guide

Taking Microgynon (a combined oral contraceptive pill) alongside cannabis (often referred to as '15' in certain contexts or slang) can make your contraception less effective, increasing the risk of an unplanned pregnancy. It can also increase the risk of side effects from the pill, such as blood clots, and may worsen the side effects of cannabis, such as a racing heart or anxiety.

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Why this happens

Cannabis can speed up the way your liver breaks down the hormones in Microgynon (estrogen and progestogen). This lowers the level of these hormones in your blood, which may prevent the pill from stopping ovulation. Additionally, both substances can increase your heart rate and affect blood pressure, putting extra strain on your cardiovascular system.

It is best to avoid using cannabis while taking Microgynon. If you do use both, you should use a barrier method of contraception (like condoms) to prevent pregnancy. You should also be aware that it is illegal to drive with any cannabis in your system in the UK, regardless of whether you feel impaired. If you experience chest pain, shortness of breath, or a very fast heartbeat, seek medical advice immediately.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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