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Can I take 200 and Zigduo together?

Drug interaction guide

Taking these two medicines together can significantly increase the risk of your blood sugar dropping too low (hypoglycaemia). It can also increase the risk of a rare but serious condition called lactic acidosis, where too much acid builds up in your blood. Additionally, both drugs can affect your kidney function, and taking them together may put extra strain on your kidneys.

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Why this happens

Both medicines work to lower blood sugar but in different ways. Celecoxib (the active ingredient in Celebrex 200) can sometimes interfere with how the body processes metformin (one of the ingredients in Xigduo), leading to higher levels of metformin in the blood. Celecoxib can also reduce blood flow to the kidneys, which makes it harder for the body to clear Xigduo.

You should speak to your doctor before taking these medicines together. If your doctor confirms you should take both, you must monitor your blood sugar levels very closely. Watch out for signs of low blood sugar, such as feeling shaky, sweaty, dizzy, or hungry. You should also stay well-hydrated to protect your kidneys. Seek medical help immediately if you feel unusually tired, have stomach pain, or have trouble breathing.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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