Can I take 60 and Alcohol together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Combining duloxetine (Cymbalta) with alcohol can increase the risk of liver damage and may worsen the side effects of the medication, such as dizziness, sleepiness, and difficulty concentrating. It can also make the symptoms of depression or anxiety worse.
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Why this happens
Both duloxetine and alcohol are processed by the liver; using them together puts extra strain on this organ. Additionally, both substances affect the central nervous system, leading to an 'additive' effect where the sedative properties of both are amplified.
What you should do
Back to contentsIt is best to avoid or strictly limit alcohol while taking duloxetine. You should never drink heavily while on this medication. If you choose to have a drink, do so only occasionally and in very small amounts, but be aware that you may feel the effects of alcohol much more quickly. Do not drive or operate machinery if you have consumed any alcohol.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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