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Can I take 75 and Magnesium multi together?

Drug interaction guide

Taking magnesium at the same time as aspirin (75mg) can make the aspirin less effective. Magnesium can act as an antacid, which may change how quickly the aspirin is absorbed or how much of it gets into your bloodstream. This is particularly important if you are taking 'baby' aspirin (75mg) to prevent heart attacks or strokes, as you need the full dose to work correctly.

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Why this happens

Magnesium compounds can increase the pH level in the stomach or bind to the aspirin, which interferes with how the medicine is absorbed into the body. It can also cause the kidneys to remove aspirin from the system more quickly.

To make sure your aspirin works properly, do not take your magnesium supplement at the same time. You should leave a gap of at least 2 to 3 hours between taking your aspirin and taking your magnesium supplement. If you have been prescribed aspirin for a heart condition, speak to your pharmacist or doctor before starting any new supplements.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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