Can I take Abilify and Effexor together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking Abilify (aripiprazole) and Effexor (venlafaxine) together can increase the risk of a rare but serious condition called serotonin syndrome. It may also increase the levels of Abilify in your blood, making side effects more likely.
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Why this happens
Both medicines increase a chemical in the brain called serotonin. If levels get too high, it causes serotonin syndrome. Additionally, Effexor can slow down the way your liver breaks down Abilify, leading to higher levels of the drug in your body.
What you should do
Back to contentsYou should only take these together if prescribed by your doctor. Watch closely for signs of serotonin syndrome, such as shivering, diarrhoea, fever, sweating, severe muscle stiffness, or confusion. If you notice these, seek medical help immediately. Your doctor may need to adjust your doses.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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