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Can I take Abiraterone and Aspirin together?

Drug interaction guide

Taking abiraterone and aspirin together may increase your risk of developing stomach ulcers or internal bleeding. Abiraterone can cause irritation to the lining of the digestive tract, and aspirin is well-known for increasing the risk of stomach bleeds. Additionally, abiraterone can sometimes cause a decrease in your blood platelet count (thrombocytopenia), which makes it harder for your blood to clot, further increasing the risk of bleeding when combined with a blood-thinner like aspirin.

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Why this happens

Abiraterone can cause gastrointestinal side effects and, in some cases, bone marrow suppression leading to low platelets. Aspirin inhibits platelet aggregation and can damage the stomach lining. Combining these effects increases the risk of gastrointestinal haemorrhage and makes it more difficult for the body to stop any bleeding that occurs.

You should use caution when taking these medicines together. It is important to tell your doctor if you are taking aspirin before starting abiraterone. Seek medical help immediately if you notice signs of bleeding, such as black or tarry stools, coughing up blood, or vomit that looks like coffee grounds. Your doctor may want to monitor your blood counts more closely or prescribe a medicine to protect your stomach.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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