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Can I take Abiraterone and Decapeptil depot together?

Drug interaction guide

Abiraterone and Decapeptyl Depot (triptorelin) are both used to treat prostate cancer. When used together, they can increase the risk of heart rhythm problems (specifically a condition called QT prolongation). They may also increase the risk of side effects like muscle pain or weakness.

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Why this happens

Both medicines can affect the electrical activity of the heart. Abiraterone can also cause low potassium levels, which makes heart rhythm issues more likely. Additionally, abiraterone can change how the body processes other drugs, potentially increasing the risk of muscle-related side effects.

This combination is often prescribed together by specialists to treat advanced prostate cancer, but it requires close monitoring. You should have regular blood tests to check your potassium and magnesium levels. Tell your doctor immediately if you feel dizzy, faint, or notice a fluttering or pounding heartbeat.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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