Can I take Acetaminophen and Lisinopril together?

Why this happens

Paracetamol and lisinopril are processed by the body through different pathways (the liver and kidneys respectively) and do not interfere with how the other is absorbed or removed from the system. While paracetamol does not block the effects of lisinopril like some other painkillers (such as ibuprofen) do, long-term use of paracetamol may slightly raise blood pressure in some people.

It is generally safe to take paracetamol for short-term pain relief while taking lisinopril. If you need to take paracetamol every day for a long time, you should have your blood pressure checked regularly by your GP. It is best to avoid or strictly limit alcohol while taking these medicines, as combining alcohol with paracetamol increases the risk of liver damage, and alcohol can also interfere with blood pressure control.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.