Can I take Acetamonophen and Amiodarone together?

Why this happens

Amiodarone is known to affect liver function and can interfere with the enzymes (specifically CYP2D6 and others) that the body uses to break down paracetamol. This can lead to a buildup of paracetamol or put extra strain on the liver.

You should use paracetamol with caution. Stick strictly to the recommended dose and do not exceed 4 grams (eight 500mg tablets) in 24 hours. It is best to avoid or strictly limit alcohol, as combining alcohol with paracetamol already increases the risk of liver damage. If you notice yellowing of the skin or eyes (jaundice), dark urine, or severe stomach pain, contact your doctor immediately.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.