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Can I take Acetazolamide and Lansoprazole together?

Drug interaction guide

Taking these two medicines together may slightly increase the risk of developing low levels of magnesium or potassium in your blood. Both medicines can affect the balance of minerals (electrolytes) in your body. While this is unlikely to cause problems for most people, it can occasionally lead to symptoms like tiredness, muscle cramps, or an irregular heartbeat.

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Why this happens

Acetazolamide is a diuretic (water tablet) that causes the kidneys to flush out minerals like potassium and magnesium. Lansoprazole is a proton pump inhibitor (PPI) which, when used long-term, can reduce the amount of magnesium the body absorbs from food. Using them together can have an additive effect on lowering these mineral levels.

It is usually fine to take these together, but you should use caution. If you are taking these medicines long-term, your doctor may occasionally want to check your mineral levels with a simple blood test. Seek medical advice if you experience unusual muscle weakness, persistent cramps, or a fluttering sensation in your chest. It is also best to avoid or strictly limit alcohol, as it can further affect your hydration and mineral balance.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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