Can I take Agomelatine and Propranolol together?

Why this happens

Agomelatine is broken down in the liver by a specific enzyme called CYP1A2. Propranolol is a 'moderate inhibitor' of this enzyme, meaning it slows down the process. This causes agomelatine to build up in your body more than it normally would.

You should speak to your doctor before taking these two medicines together. They may need to adjust your dose of agomelatine or monitor you more closely for side effects. Do not stop taking your prescribed medication without medical advice.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.