Can I take Alogliptin and Amlodipine together?

Why this happens

Alogliptin (used for type 2 diabetes) and amlodipine (used for high blood pressure) are processed by different pathways in the body. Alogliptin is primarily cleared by the kidneys, while amlodipine is broken down by the liver. They do not interfere with how each other works or how they are removed from the system.

What you should do

You can continue to take both medications as prescribed by your doctor. As with any combination of medicines for blood pressure and diabetes, it is always a good idea to monitor your blood sugar and blood pressure regularly to ensure your conditions are well-managed.

Important precautions

Pancreatitis

Stop taking alogliptin and see a doctor immediately if you experience severe and persistent stomach pain, which may reach through to your back, as this can be a sign of an inflamed pancreas

Liver problems

If you have liver disease, your dose may need to be adjusted or monitored more closely as amlodipine is broken down by the liver and can build up in your system.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. Avoid drinking large amounts of grapefruit juice.

Alcohol

While there is no direct interaction, alcohol can lower your blood pressure (with amlodipine) or affect your blood sugar levels (with alogliptin). It is best to keep your intake within recommended limits and monitor how you feel.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.