Can I take Amisulpride and Prednisolone together?
Drug interaction guide
Originally published 12 May 2026
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Taking these two medicines together may increase the risk of developing an irregular heart rhythm or an electrolyte imbalance (low potassium levels). It can also increase the risk of experiencing side effects like restlessness or muscle stiffness.
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Why this happens
Amisulpride can affect the electrical activity of the heart (prolonging the QT interval). Prednisolone can cause the body to lose potassium. When potassium levels are low, the heart is more sensitive to the effects of amisulpride, making heart rhythm problems more likely. Additionally, both drugs can affect the central nervous system.
What you should do
Back to contentsYou should speak to your doctor before taking these together. They may want to perform a blood test to check your potassium and magnesium levels, or an ECG (heart trace) to ensure your heart rhythm is normal. Seek medical help immediately if you feel dizzy, faint, or notice a fluttering or pounding heartbeat.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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