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Can I take Amlodipine and Ciprofloxacin together?

Drug interaction guide

Taking these two medicines together can cause your blood pressure to drop lower than intended. It may also increase the amount of amlodipine in your blood, which can lead to side effects like swelling in the ankles, headaches, or a flushing sensation. In rare cases, this combination might affect your heart rhythm.

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Why this happens

Ciprofloxacin can slow down the way your liver processes amlodipine (by blocking an enzyme called CYP3A4). This means amlodipine stays in your system longer and at higher levels. Additionally, both drugs have a small potential to affect the electrical activity of the heart, which could have an additive effect.

You can usually take these together, but you should monitor your blood pressure more closely. If you feel dizzy, lightheaded, or notice your heart racing or skipping a beat, contact your doctor. Your doctor may need to adjust your amlodipine dose while you are finishing your course of antibiotics.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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