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Can I take Amlodipine and Dooxylamine together?

Drug interaction guide

Taking amlodipine and doxylamine together may cause your blood pressure to drop lower than intended. This can make you feel dizzy, lightheaded, or faint, especially when standing up quickly. You may also experience increased drowsiness or sleepiness.

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Why this happens

Both medications can lower blood pressure (amlodipine is a blood pressure treatment, and doxylamine has a side effect of lowering blood pressure). Additionally, doxylamine is a sedating antihistamine that can cause tiredness, which may be more noticeable when your blood pressure is low.

Use caution when combining these medicines. It is best to take doxylamine at bedtime. When moving from a lying or sitting position to standing, do so slowly to avoid dizziness. If you feel very dizzy, faint, or unusually sleepy, contact your doctor or pharmacist.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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