Can I take Amlodipine and Homocysteine nutrients together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking homocysteine-lowering nutrients (such as Vitamin B6, B12, and Folic Acid) alongside amlodipine may lead to a more pronounced reduction in blood pressure than taking amlodipine alone. While this is generally a positive health effect, it could occasionally cause blood pressure to drop slightly lower than intended.
In this article:
Continue reading below
Why this happens
Both amlodipine and B-vitamins (which lower homocysteine) help improve the health and relaxation of blood vessels. Amlodipine blocks calcium from entering the muscle cells of the heart and arteries, while lowering homocysteine reduces oxidative stress and improves the lining of the blood vessels. Together, they have an additive effect on lowering blood pressure.
What you should do
Back to contentsIt is generally safe to take these together. However, you should monitor your blood pressure regularly when starting the supplements. If you feel dizzy, lightheaded, or unusually tired, speak to your doctor, as they may need to adjust your blood pressure medication dosage.
Continue reading below
Important precautions
Back to contentsGrapefruit consumption
Avoid grapefruit juice and grapefruit. It can significantly increase the level of amlodipine in your blood, causing your blood pressure to drop dangerously low.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the amount of amlodipine in your blood. While the effect is usually small, it is best to avoid drinking large amounts of grapefruit juice to prevent your blood pressure from dropping too low.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Desmopressin and Ketoconazole together?
Taking these two medicines together can significantly increase the amount of desmopressin in your blood. This can lead to your body holding onto too much water, which can cause a dangerous drop in your blood salt levels (hyponatraemia). Symptoms to watch for include severe headache, nausea, vomiting, confusion, or feeling very drowsy.
Treatment and medication
Can I take Levothyroxine and Ramipril together?
There is no direct interaction between levothyroxine and ramipril. However, if your thyroid levels are not well-controlled, it can affect how well your blood pressure medication works.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.