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Can I take Amlodipine and Ozempic together?

Drug interaction guide

While there is no direct 'clash' between these two medicines, Ozempic can sometimes cause a slight increase in heart rate or changes in blood pressure. Since amlodipine is used to lower blood pressure, the combination might occasionally lead to your blood pressure dropping a bit lower than intended, or you might feel slightly dizzy when standing up. Additionally, Ozempic slows down how quickly your stomach empties, which can theoretically change how other tablets are absorbed, though this rarely causes issues with amlodipine.

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Why this happens

Ozempic (semaglutide) mimics a hormone that slows gastric emptying (how fast food and pills leave the stomach). This can alter the timing of how amlodipine enters your system. Furthermore, both drugs can affect the cardiovascular system in different ways—amlodipine relaxes blood vessels to lower pressure, while Ozempic can slightly increase heart rate.

You can generally take these two medicines together safely. However, you should monitor your blood pressure regularly at home, especially when you first start Ozempic or when your dose is increased. If you feel dizzy, lightheaded, or faint, speak to your doctor, as they may need to adjust your blood pressure medication.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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