Can I take Amlodopine and Losartan together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking these two medicines together can cause your blood pressure to drop lower than if you took either one alone. While this is often the goal of treatment, it can sometimes lead to symptoms like dizziness, lightheadedness, or fainting, especially when you stand up quickly. There is also a small risk of affecting your kidney function or increasing potassium levels in your blood.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both medicines work to lower blood pressure but in different ways: amlodipine relaxes the blood vessels directly, while losartan blocks a hormone (angiotensin II) that normally makes blood vessels tighten. Because they attack the problem from two different angles, their effects add together.
What you should do
Back to contentsThis is a very common and effective combination used by doctors to treat high blood pressure. You should continue taking both as prescribed. To stay safe, stand up slowly from a sitting or lying position to avoid dizziness. Your doctor will likely monitor your blood pressure regularly and may perform occasional blood tests to check your kidney function and potassium levels. Contact your doctor if you feel severely dizzy or unusually tired.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Apixaban and Empagliflozin together?
There is no known direct interaction between apixaban and empagliflozin. It is generally considered safe to take these two medications together.

Treatment and medication
Can I take St John's wort and Vitamin B2 together?
There is no known harmful interaction between St John's Wort and Vitamin B2 (riboflavin). Taking them together is generally considered safe.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.