Skip to main content

Can I take Aspirin and Citalopram together?

Drug interaction guide

Taking aspirin and citalopram together increases your risk of bleeding, particularly in the stomach or gut. You may bruise more easily, or notice that small cuts take longer to stop bleeding. In more serious cases, it can lead to internal bleeding, which might show up as very dark or 'tar-like' stools, or vomiting blood.

Video picks for Drug interactions

Continue reading below

Why this happens

Both medicines affect how your blood clots. Aspirin prevents blood cells called platelets from sticking together. Citalopram (an SSRI antidepressant) also reduces the amount of serotonin in your platelets, which they need to help form clots. When used together, these two different effects combine to make your blood much thinner than usual.

Speak to your doctor before taking these together. If your doctor has prescribed both, they may suggest a 'stomach-protecting' medicine (like omeprazole) to reduce the risk of ulcers. Seek immediate medical help if you notice signs of serious bleeding, such as black/tarry stools, coughing up blood, or severe stomach pain.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.