Can I take Bisoprolol and Lercanidipine together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking bisoprolol and lercanidipine together can cause your blood pressure to drop lower than if you took either medicine alone. It can also slow down your heart rate more than usual. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly.
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Why this happens
Both medicines work to lower blood pressure but in different ways: bisoprolol is a 'beta-blocker' that slows the heart, while lercanidipine is a 'calcium channel blocker' that widens blood vessels. When used together, their effects add up (an additive effect), which can significantly lower blood pressure and heart rate.
What you should do
Back to contentsThis combination is common and often prescribed by doctors to treat high blood pressure, but you should be monitored closely. When you first start taking them together, or if your dose is increased, take extra care when standing up. If you feel very dizzy, tired, or notice a very slow pulse, contact your doctor. Do not stop taking either medicine without medical advice.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take 7.5mg and Medikinet together?
Taking Zopiclone and Medikinet (methylphenidate) together can cause a 'tug-of-war' effect in your body. Medikinet is a stimulant designed to wake you up and help you focus, while Zopiclone is a sedative designed to make you sleepy. Taking them at the same time can make both medicines less effective. Additionally, while Medikinet is active, it may be harder for you to fall asleep, even after taking Zopiclone. In some cases, mixing stimulants and sedatives can lead to unpredictable effects on your coordination, heart rate, or mental state (such as feeling confused or agitated).
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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