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Can I take Co-codamol and Lansoprazole together?

Drug interaction guide

There is no direct harmful interaction between co-codamol and lansoprazole. However, co-codamol contains codeine, which can cause constipation. Lansoprazole is often used to treat stomach issues, and while it doesn't interact with the medicine itself, the side effects of codeine might complicate certain digestive conditions.

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Why this happens

Lansoprazole reduces stomach acid (a proton pump inhibitor), while co-codamol is a combination of paracetamol and codeine. These drugs are processed by different pathways in the liver and do not significantly interfere with each other's absorption or effectiveness.

It is generally safe to take these two medicines together. If you are taking lansoprazole for an ulcer or severe indigestion, be aware that the codeine in co-codamol can cause constipation, which may cause abdominal discomfort. Drink plenty of water and speak to a pharmacist if you experience constipation.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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