Can I take Coxicel and Mydocalm together?

Why this happens

Coxicel (celecoxib) can inhibit a specific liver enzyme (CYP2D6) that helps break down certain drugs. While Mydocalm (tolperisone) is mainly broken down by other pathways, there is a minor overlap that could lead to higher levels of Mydocalm. Additionally, both drugs can cause dizziness as a side effect, which may be more noticeable when taken together.

It is generally safe to take these together, but you should be cautious when first starting the combination. Monitor how you feel, especially for increased sleepiness or lightheadedness. Avoid driving or operating machinery until you know how this combination affects you. If you feel very dizzy or faint, contact your doctor.

Heart disease or stroke history

You must not take this medicine if you have established heart disease, have had a stroke, or have severe heart failure, as it significantly increases the risk of serious cardiovascular events.

Sulphonamide (sulfa) allergy

Do not take this medicine if you are allergic to sulphonamide medicines (such as certain antibiotics), as you are likely to have a severe allergic reaction to celecoxib.

Hypersensitivity (Allergy)

This medicine carries a high risk of severe allergic reactions. If you experience flushing, rash, or difficulty breathing, stop taking it immediately and seek urgent medical help. Do not restart it if you have ever had a reaction to it.

Alcohol

Drinking alcohol while taking Coxicel can increase your risk of developing stomach ulcers or internal bleeding. It is best to limit or avoid alcohol during treatment.

High-fat meals

Taking Coxicel with a high-fat meal can delay its absorption, meaning it may take longer to start working. However, it can be taken with or without food. If it upsets your stomach, taking it with food may help.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.