Can I take Crestor and Pepcid ac together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking Pepcid AC (famotidine) at the same time as Crestor (rosuvastatin) can lower the amount of Crestor that your body absorbs. This might make your cholesterol medication less effective at lowering your 'bad' cholesterol levels.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Pepcid AC reduces the amount of acid in your stomach. Crestor needs a certain level of acidity to be absorbed properly into your bloodstream. When stomach acid is lowered, less of the medicine gets into your system.
What you should do
Back to contentsYou can still take both medications, but you should space them out. Take your Crestor at least 2 hours before or 2 hours after taking Pepcid AC to ensure your body absorbs the full dose of your cholesterol medicine.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Drug interactions checker
Can I take Black garlic and Ginger together?
Taking black garlic and ginger together may increase your risk of bruising or bleeding. This is because both supplements can slow down the time it takes for your blood to clot. While this is usually not a problem for healthy people, it can be significant if you are already taking blood-thinning medications or have an upcoming surgery.
Drug interactions checker
Can I take Calcium and Esomeprazole together?
Taking esomeprazole for a long time may reduce how much calcium your body absorbs from your diet or from certain supplements. This can lead to weaker bones and an increased risk of fractures, particularly in the hip, wrist, or spine, if used at high doses for over a year.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.