Can I take Isosorbate mononotrate and Nebivolol together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking these two medicines together can cause your blood pressure to drop lower than usual. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly from a sitting or lying position. You may also feel more tired or experience a headache.
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Why this happens
Both medicines work to lower blood pressure and improve blood flow, but in different ways. Isosorbide mononitrate (a nitrate) relaxes and widens your blood vessels, while nebivolol (a beta-blocker) slows your heart rate and reduces the force of your heartbeat. When used together, their effects add up, which can lead to an exaggerated drop in blood pressure.
What you should do
Back to contentsIt is common for these medicines to be prescribed together, but you should be cautious. When starting this combination or changing your dose, get up slowly from a sitting or lying position to avoid dizziness. Monitor your blood pressure regularly if advised by your doctor. If you feel very dizzy, faint, or have a persistent headache, contact your GP or pharmacist. Do not stop taking either medicine without speaking to your doctor first.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking these two medicines together can significantly increase the amount of desmopressin in your blood. This can lead to your body holding onto too much water, which can cause a dangerous drop in your blood salt levels (hyponatraemia). Symptoms to watch for include severe headache, nausea, vomiting, confusion, or feeling very drowsy.
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Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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