Can I take Losartan and Sertraline together?

Why this happens

Both medicines can independently lower blood pressure. Losartan is designed to do this, while sertraline can sometimes cause low blood pressure as a side effect. Additionally, both drugs are linked to a condition called hyponatraemia (low blood sodium), particularly in older patients.

It is generally safe to take these together, but you should be mindful of how you feel. If you feel dizzy or lightheaded, sit or lie down until the feeling passes. Rise slowly from a sitting or lying position. If you experience persistent dizziness, confusion, or extreme tiredness, mention it to your doctor, as they may want to check your blood pressure or perform a simple blood test to check your salt levels.

Depression and anxiety disorders

You may experience an increase in suicidal thoughts or the urge to self-harm when first starting sertraline or changing the dose. This is more common in young adults under 25. Contact your doctor or go to hospital immediately if you notice any changes in your mood or behaviour.

Bleeding risk

Sertraline increases the risk of bleeding, especially if taken with aspirin, ibuprofen, or blood-thinning medications. Seek medical advice if you notice unusual bruising or signs of bleeding.

Pregnancy

You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.

Serotonin Syndrome

Sertraline can cause a life-threatening condition called serotonin syndrome, especially if taken with other medicines that affect serotonin (such as triptans, tramadol, or St John's Wort). Seek urgent medical help if you experience agitation, hallucinations, fast heartbeat, or severe muscle stiffness.

Alcohol

It is best to avoid or strictly limit alcohol while taking losartan. Alcohol can increase the blood pressure-lowering effect of losartan, which may make you feel dizzy, lightheaded, or faint, especially when standing up. Combining alcohol with medication also increases the risk of liver damage.

It is best to avoid or strictly limit alcohol while taking sertraline. Combining alcohol with this medicine can increase side effects such as drowsiness, dizziness, and impaired coordination. It may also make your depression or anxiety symptoms worse.

Potassium-rich foods (e.g., bananas, spinach, salt substitutes)

Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.

Caffeine

Sertraline can sometimes make you feel restless or anxious. Caffeine (found in coffee, tea, and energy drinks) is a stimulant that may worsen these side effects. If you feel jittery, it is best to limit your caffeine intake.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.