Can I take Magnesium and Pregabalin together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking magnesium and pregabalin together may make you feel more sleepy, dizzy, or unsteady on your feet. There is also a small chance that magnesium could slightly reduce how much pregabalin your body absorbs, making it less effective.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Both substances can slow down the central nervous system (the brain and nerves), leading to an 'additive' effect where the side effects of both are stronger. Additionally, some minerals like magnesium can physically bind to certain medications in the stomach, potentially lowering the amount of medicine that gets into your bloodstream.
What you should do
Back to contentsIt is generally safe to take both, but you should be aware of increased drowsiness. To ensure you get the full benefit of your pregabalin, try to space the doses out by at least 2 hours. If you feel unusually sleepy or dizzy, avoid driving or using machinery until you know how the combination affects you.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Atorvastatin and Magnesium together?
Taking magnesium antacids at the same time as atorvastatin can lower the amount of the statin medicine that your body absorbs. This might make your cholesterol treatment less effective.

Treatment and medication
Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.