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Aktiv, aber nicht rekrutierendPHASE2INTERVENTIONELL

Study With Various Immunotherapy Treatments in Participants With Lung Cancer

This research study is for people with advanced non-small cell lung cancer. It's testing different combinations of new medicines, including ones called Domvanalimab, Quemliclustat, and Zimberelimab, sometimes with existing treatments like Docetaxel. The main aim is to find out how effective these new combinations are at shrinking or controlling the cancer (this is called the 'objective response rate'). Researchers also want to understand how safe these new treatments are and what side effects they might cause. By looking at these things, the study hopes to discover better treatment options for this kind of cancer.

Auf einen Blick

Status
Aktiv, aber nicht rekrutierend
Phase
PHASE2
Sponsor
Gilead Sciences
Einschreibeziel
400
Starten
21. Feb 2023
Geschätzte Fertigstellung
01 Dez 2027
Fortgeschrittener nicht-kleinzelliger Lungenkrebs

Worum geht es in dieser Studie?

This study is exploring potential new ways to treat a type of lung cancer called advanced non-small cell lung cancer. In this study, doctors are testing different combinations of new medications, often referred to as 'immunotherapy'. Immunotherapy works by helping your body's own immune system fight the cancer cells.

The study has a few main goals. Firstly, it wants to see how well these new combinations shrink the cancer or stop it from growing. This is important for understanding if the treatments are effective. Secondly, the researchers are carefully checking the safety of these new medicine combinations. They want to know what possible side effects might occur and how well people tolerate the treatments. This will help them understand if the treatments are not only effective but also manageable for patients.

By carefully studying these new combinations, the researchers hope to find more effective and safer treatment options for people living with advanced non-small cell lung cancer. This work is a step towards improving care and offering more choices for patients in the future.

Wichtige Erkenntnisse

  • This study evaluates new immunotherapy combinations for advanced lung cancer.
  • It aims to find effective and safe new treatment options.
  • Participation involves regular medical check-ups and monitoring.
  • You might receive new treatments not yet widely available.
  • Your health and safety are a top priority throughout the study.

Wer könnte berechtigt sein?

To join this study, you would need to have advanced non-small cell lung cancer that has spread. Doctors would check that your general health is good enough for you to take part, and that the cancer can be measured. You would also need to be willing to provide a small sample of your tumour tissue for testing.

There are also some reasons why you might not be able to join. For example, if you have other serious health problems that the doctors think would make the study medicines unsafe for you. You also couldn't have had certain live vaccinations recently, or be taking high doses of steroid medications or other medicines that suppress your immune system just before starting the study. Certain autoimmune diseases might also prevent you from joining.

Könnte diese Studie für Sie geeignet sein?

Beantworten Sie diese kurzen Fragen, um zu sehen, ob Sie möglicherweise berechtigt sind. Dies ist nur ein Leitfaden – das Forschungsteam trifft die endgültige Entscheidung.

  1. Do you have advanced non-small cell lung cancer that has spread?
  2. Is your general health good enough for you to take part?
  3. Do you have cancer that doctors can measure?
  4. Are you willing to provide a tumour tissue sample?
  5. Have you avoided live vaccines in the last 28 days?
  6. Are you taking any high-dose steroid or immune-suppressing medicines?
Beantworten Sie jede Frage, um Ihr Ergebnis zu sehen.

Was beinhaltet die Teilnahme?

If you decide to take part in this study, you would receive one of the new medicine combinations. You would have regular visits to the clinic for check-ups, where doctors would monitor your health and how the treatment is affecting you. This would include tests like blood samples and scans to see how your cancer is responding. The doctors and nurses would also ask about any side effects you might be experiencing. The exact number of visits and tests, and the total length of time you'd be in the study, would be explained to you in detail.

Potenzielle Risiken und Vorteile

Participating in this study might offer you access to new treatments before they are widely available. While there's no guarantee the treatment will work for you, it could potentially help control your cancer. However, all medicines have potential side effects, and some of the treatments in this study are new, so not all side effects might be fully known. Your health will be closely monitored, and you can withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Standorte (53)

  • University of Alabama at Birmingham (UAB)
    Verifizierte Postleitzahl
    Birmingham, Vereinigte Staaten
  • University of California San Diego (UCSD)
    Verifizierte Postleitzahl
    La Jolla, Vereinigte Staaten
  • Memorial Cancer Institute at Memorial Regional Hospital
    Verifizierte Postleitzahl
    Hollywood, Vereinigte Staaten
  • Hematology Oncology Associates Of The Treasure Coast
    Verifizierte Postleitzahl
    Port Saint Lucie, United States
  • Florida Cancer Specialists (Administration and Drug Shipment)
    Verifizierte Postleitzahl
    The Villages, United States
  • Northwestern Memorial Hospital
    Verifizierte Postleitzahl
    Chicago, Vereinigte Staaten
  • Ochsner Clinic Foundation
    Verifizierte Postleitzahl
    Jefferson, United States
  • Henry Ford Hospital
    Verifizierte Postleitzahl
    Detroit, Vereinigte Staaten
  • Virginia Cancer Specialists, PC
    Verifizierte Postleitzahl
    Fairfax, Vereinigte Staaten
  • Medical Oncology Associated, PS (dba Summit Cancer Centers)
    Verifizierte Postleitzahl
    Spokane, United States
  • The Border Cancer Hospital
    Verifizierte Postleitzahl
    Albury, Australia
  • Pindara Private Hospital
    Verifizierte Postleitzahl
    Benowa, Australia

Häufige Fragen

What is non-small cell lung cancer?

It's the most common type of lung cancer, and 'advanced' means it has spread to other parts of the body.

Was ist Immuntherapie?

Immunotherapy helps your body's own defence system fight cancer cells by boosting its ability to recognise and attack them.

What does a 'combination therapy' mean?

It means you'll be given more than one medicine at the same time, as they might work better together than alone.

Werde ich wissen, welche Behandlung ich bekomme?

The study design details this. You will be fully informed before deciding to take part.

Was passiert, nachdem die Studie endet?

This will be discussed with you, but your care will always be continued by your regular medical team.

Wie Sie mehr erfahren können

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Sprechen Sie immer mit Ihrem Hausarzt oder Spezialisten, bevor Sie sich entscheiden, an einer Studie teilzunehmen.

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