Intranasal Insulin and Olanzapine Study in Healthy Volunteers

This study is looking for healthy volunteers to take part. For the part of the study focused on understanding how your body processes sugar, you need to be between 17 and 65 years old. If you're interested in the part of the study that looks at thinking skills and uses special brain scans (MRI), you need to be between 17 and 45 years old, and you must be right-handed.

There are certain conditions that would mean you can't join. This includes if you have ever had a mental health illness, although for the sugar-processing part of the study, some anxiety disorders may be allowed. You also can't have pre-diabetes, diabetes, a family history of diabetes, or any problems with your liver or kidneys. Pregnant or breastfeeding individuals cannot participate, nor can anyone who has had a major illness or surgery recently.

If you're considering the brain scan part of the study, you cannot have any metal implants in your body (like a pacemaker) or suffer from claustrophobia (a fear of enclosed spaces), as these would make MRI scans unsafe or impossible.

If you join this study, you might take part in one of two main parts: one focusing on how your body handles sugar, and another looking at your brain's activity and thinking skills. Some volunteers might participate in both. You'll receive either a single dose of the medicine olanzapine, a placebo (a dummy pill), a nasal spray of insulin, or a saline (saltwater) nasal spray.

The sugar-handling part of the study involves a special procedure called a pancreatic euglycemic clamp (PEC), which will carefully measure how your body processes sugar. The brain activity part involves MRI scans and tests of your memory and thinking skills. The total duration of your participation, including the number of visits and follow-up, will be explained in detail by the study team, but generally involves a few visits to the clinic.