Liver Transplantation for Locally Advanced Intrahepatic Cholangiocarcinoma After SIRT and Chemotherapy

To join this study, people generally need to be between 18 and 65 years old. You must have a confirmed diagnosis of intrahepatic cholangiocarcinoma that is located only in the liver, with no more than 5 small tumours, and doctors must agree that it's not possible to remove the cancer with standard surgery. The cancer needs to be a certain size, and your general health should be good enough to undergo demanding treatments.

There are also reasons why someone might not be able to join. For example, if your liver cancer is a different type or has already spread outside the liver, or if more than half of your liver is affected by the tumour. You also cannot join if you have certain other serious health problems, such as severe heart, kidney, or psychiatric conditions, or if you've had certain other cancers recently. Severe liver scarring (cirrhosis) would also prevent you from participating.

Women who are pregnant or breastfeeding, or anyone currently involved in another medical study that involves an intervention, cannot take part. Everyone who joins must give their full permission and, if they can have children, agree to use effective birth control during and for two years after the study.

If you join this study, you would first receive a special type of radiation therapy called SIRT, along with chemotherapy. After these treatments, doctors will do detailed scans (like CT, MRI, and PET-CT) to see how the cancer has responded. If the cancer has improved or hasn't gotten worse, and if other safety checks are met, you might then have exploratory surgery to make sure a liver transplant is safe. Following this, you would be placed on a waiting list for a liver transplant, with a minimum waiting period of three months. After the transplant, you would need regular check-ups to monitor your new liver's health, how well the anti-rejection medicines are working, and your overall well-being. The total duration of your involvement, including follow-up, could extend for a significant period following the transplant.