Obe-cel in Refractory Progressive Forms of Multiple Sclerosis

To join this study, you need to be an adult between 18 and 60 years old. You must have a current diagnosis of a progressive form of MS and have already tried at least two other strong MS medications without enough success. It's also important that you are able and willing to follow all the study's instructions and attend appointments.

There are also reasons why someone might not be able to join. For example, if you are pregnant or breastfeeding, or if you have another autoimmune condition affecting your brain and spinal cord, you wouldn't be eligible. People with active infections, certain types of cancer in the last two years, or a history of major organ transplants (like heart, lung, kidney, liver, or bone marrow) would also not be able to take part. The study also cannot accept people with very active MS, as described by certain medical criteria.

If you decide to take part in this study, you'll first have a 'screening period' lasting up to a month. During this time, doctors will do tests and checks to make sure the study is suitable for you. If you qualify, you'll then enter a 'treatment period'. This involves receiving chemotherapy over 1 to 3 days, followed by a single infusion of the obe-cel treatment on a specific day, referred to as Day 1. The chemotherapy is used to prepare your body for the obe-cel, not to treat cancer.

After receiving obe-cel, you will be very closely monitored for the first 28 days. Following this initial period, you'll continue to have regular check-ups and assessments by the study team, who will monitor your health, look for any side effects, and see how your MS is doing. This follow-up will continue for up to 24 months (two years). During this time, you'll need to attend all scheduled appointments and follow the study's instructions.