homeobox B13

Normal function

Der HOXB13 gene provides instructions for producing a protein that attaches (binds) to specific regions of DNA and regulates the activity of other genes. On the basis of this role, the protein produced from the HOXB13 gene is called a transcription factor. The HOXB13 protein is part of a large group of transcription factors called the homeobox protein family. The HOXB13 protein is thought to play a role in the development and maintenance of the skin. It also acts as a tumour suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way.

The HOXB13 protein has a characteristic homeobox region called the homeodomain, which binds to DNA, and two other regions called MEIS interacting domains. The MEIS interacting domains are thought to help regulate the activity of the HOXB13 protein by controlling the binding of the homeodomain with DNA.

Conditions referring to this gene or chromosome

• Prostatakrebs

Other names

homeobox protein Hox-B13

HXB13_HUMAN

PSGD