integrin subunit beta 3
Zuletzt aktualisiert 18. Aug 2020
Erfüllt die redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen
- Language
- Diskussion
- Audio-Version
- Zu bevorzugten Quellen bei Google hinzufügen
Der ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. Platelets circulate in blood and are an essential component of blood clots. The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. It is estimated that 80,000 to 100,000 copies of integrin αIIbβ3 are present on the surface of each platelet.
Normal function
Der ITGB3 gene provides instructions for making the beta3 subunit of a receptor protein called integrin alphaIIb/beta3 (αIIbβ3), which is found on the surface of small cells called platelets. Platelets circulate in blood and are an essential component of blood clots. The beta3 subunit attaches (binds) to the alphaIIb subunit, which is produced from the ITGA2B gene, to form integrin αIIbβ3. It is estimated that 80,000 to 100,000 copies of integrin αIIbβ3 are present on the surface of each platelet.
During clot formation, integrin αIIbβ3 binds to a protein called fibrinogen. Attachment of integrin αIIbβ3 from adjacent platelets to the same fibrinogen protein helps platelets cluster together (platelet cohesion) to form a blood clot. Blood clots protect the body after injury by sealing off damaged blood vessels and preventing further blood loss. Integrin αIIbβ3 can also bind other proteins on platelets and in the blood as well as proteins within the intricate lattice that forms in the space between cells (extracellular matrix) to ensure proper clot formation and promote wound healing.
Conditions referring to this gene or chromosome
Other names
beta 3 integrin
CD61
GP3A
GPIIIa
integrin beta 3
integrin beta-3 precursor
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
platelet glycoprotein IIIa
platelet GPIIIa
platelet membrane glycoprotein IIIa
vitronectin receptor beta chain
Related patient information and medicines
Patient information leaflet
Kann ich Lansoprazol und Mirabegron zusammen einnehmen?
There are no known significant interactions between lansopra... It is generally considered safe to take these two medications together. Why this happens Lansoprazole is a proton pump inhibitor used to reduce stomach acid, while mirabegron is a beta-3 adrenergic agonist used for overactive bladder. They are processed by different pathways in the.
Patient information leaflet
Kann ich Atorvastatin und Bisoprolol zusammen einnehmen?
Warum das passiert Atorvastatin is a statin used to lower cholesterol, and bisoprolol is a beta-blocker used to manage blood pressure and heart rate. They are processed by different pathways in the body and do ... Our Wechselwirkungs-Checker für Medikamente helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to.
Patient information leaflet
Kann ich Alogliptin und Bisoprolol zusammen einnehmen?
It can also slightly increase the risk of your blood suga... Why this happens Bisoprolol is a beta-blocker. These medicines can mask the physical symptoms of low blood sugar, such as a fast heartbeat or tremors. Our Wechselwirkungs-Checker für Medikamente helps you check whether dein prescriptions, over-the-counter medicines, and supplements are safe to.
Patient information leaflet
Kann ich Allopurinol und Co-amoxiclav zusammen einnehmen?
Taking allopurinol and co-amoxiclav together increases the risk of developing a skin rash. While most rashes are mild, there is a... Penicillin allergy Do not take Co-Amoxiclav if you have ever had a severe allergic reaction (such as Anaphylaxie or a skin rash) zur Penicillin or any other 'beta-lactam' antibiotic, as this can be fatal. Disclaimer.
Patient information leaflet
Kann ich Bisoprolol und Trimbow zusammen einnehmen?
Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Why this happens Bisoprolol ist a 'beta-blocker' and formoterol (in Trimbow) is a 'beta-agonist'. Important precautions Acute breathing distress Bisoprolol ist a beta-blocker and can cause narrowing of the airways, potentially triggering a severe asthma attack.
Patient information leaflet
Kann ich Bisoprolol und Metformin zusammen einnehmen?
It may also slightly change how your body manages blood sugar levels, potentially making metformin less effective or inc... Why this happens Bisoprolol ist a beta-blocker. It works by slowing the heart rate and blocking certain stress hormones. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions.
Weiterführende Lektüre und Referenzen
- integrin subunit beta 3; MedlinePlus, National Library of Medicine.
- Kobayashi Y, Matsui H, Kanai A, Tsumura M, Okada S, Miki M, Nakamura K, Kunishima S, Inaba T, Kobayashi M. Identification of the integrin beta3 L718P mutation in a pedigree with autosomal dominant thrombocytopenia with anisocytosis. Br J Haematol. 2013 Feb;160(4):521-9. doi: 10.1111/bjh.12160. Epub 2012 Dec 17.
- Nurden AT, Fiore M, Nurden P, Pillois X. Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models. Blood. 2011 Dec 1;118(23):5996-6005. doi: 10.1182/blood-2011-07-365635. Epub 2011 Sep 13.
- Nurden AT, Pillois X, Fiore M, Alessi MC, Bonduel M, Dreyfus M, Goudemand J, Gruel Y, Benabdallah-Guerida S, Latger-Cannard V, Negrier C, Nugent D, Oiron RD, Rand ML, Sie P, Trossaert M, Alberio L, Martins N, Sirvain-Trukniewicz P, Couloux A, Canault M, Fronthroth JP, Fretigny M, Nurden P, Heilig R, Vinciguerra C. Expanding the Mutation Spectrum Affecting alphaIIbbeta3 Integrin in Glanzmann Thrombasthenia: Screening of the ITGA2B and ITGB3 Genes in a Large International Cohort. Hum Mutat. 2015 May;36(5):548-61. doi: 10.1002/humu.22776.
- Nurden AT, Pillois X, Fiore M, Heilig R, Nurden P. Glanzmann thrombasthenia-like syndromes associated with Macrothrombocytopenias and mutations in the genes encoding the alphaIIbbeta3 integrin. Semin Thromb Hemost. 2011 Sep;37(6):698-706. doi: 10.1055/s-0031-1291380. Epub 2011 Nov 18.
- Pillitteri D, Pilgrimm AK, Kirchmaier CM. Novel Mutations in the GPIIb and GPIIIa Genes in Glanzmann Thrombasthenia. Transfus Med Hemother. 2010;37(5):268-277. doi: 10.1159/000320258. Epub 2010 Sep 15.
Artikelverlauf
Artikel auch verfügbar in Englisch, Deutsch, Spanisch, Französisch, Italienisch, Portugiesisch, Hindi, Hebräisch, Arabisch, und Schwedisch.
18. Aug 2020 | Neueste Version
1 Sept 2015 | Ursprünglich veröffentlicht
Nehmen Sie an der Diskussion teil
Teilen Sie Ihre Gedanken oder Erfahrungen mit anderen in unserem Patientengemeinschaften.
Fragen, teilen, verbinden.
Durchsuchen Sie Diskussionen, stellen Sie Fragen und teilen Sie Erfahrungen zu Hunderten von Gesundheitsthemen.
Abonnieren Sie den Patienten-Newsletter
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsberatung - geschrieben, um Ihnen zu helfen, sich informiert, selbstbewusst und in Kontrolle zu fühlen.
Durch das Abonnieren akzeptieren Sie unsere Datenschutzrichtlinie. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals.