laminin subunit beta 3
Zuletzt aktualisiert 3 Apr 2025
Erfüllt die redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen
- Language
- Diskussion
- Audio-Version
- Zu bevorzugten Quellen bei Google hinzufügen
Der LAMB3 gene provides instructions for making one part (subunit) of a protein called laminin 332 (formerly known as laminin 5). This protein is made up of three subunits, called alpha, beta, and gamma. The LAMB3 gene carries instructions for the beta subunit; the alpha and gamma subunits are produced from other genes.
Normal function
Der LAMB3 gene provides instructions for making one part (subunit) of a protein called laminin 332 (formerly known as laminin 5). This protein is made up of three subunits, called alpha, beta, and gamma. The LAMB3 gene carries instructions for the beta subunit; the alpha and gamma subunits are produced from other genes.
Laminins are a group of proteins that regulate cell growth, cell movement (motility), and the attachment of cells to one another (adhesion). They are also involved in the formation and organisation of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Laminin 332 has a particularly important role in the basement membrane that underlies the top layer of skin (the epidermis). This membrane gives strength and resiliency to the skin and creates an additional barrier between the body and its surrounding environment. Laminin 332 is a major component of fibers called anchoring filaments, which connect the two layers of the basement membrane and help hold the skin together.
Studies suggest that laminin 332 also has several other functions. This protein appears to be important for wound healing. Additionally, researchers have proposed roles for laminin 332 in the clear outer covering of the eye (the cornea) and in the development of tooth enamel.
Conditions referring to this gene or chromosome
Other names
BM600-125KDA
FLJ99565
kalinin B1 chain
kalinin-140kDa
LAM5, beta-3 subunit
LAMB3_HUMAN
laminin 5, beta-3 subunit
laminin B1k chain
laminin B3
laminin S B3 chain
laminin, beta 3
laminin, beta 3 precursor
laminin, beta-3
LAMNB1
nicein-125kDa
Related patient information and medicines
Patient information leaflet
Kann ich Lansoprazol und Mirabegron zusammen einnehmen?
There are no known significant interactions between lansopra... It is generally considered safe to take these two medications together. Why this happens Lansoprazole is a proton pump inhibitor used to reduce stomach acid, while mirabegron is a beta-3 adrenergic agonist used for overactive bladder. They are processed by different pathways in the.
Patient information leaflet
Kann ich Alogliptin und Bisoprolol zusammen einnehmen?
It can also slightly increase the risk of your blood suga... Why this happens Bisoprolol ist a beta-blocker. These medicines can mask the physical symptoms of low blood sugar, such as a fast heartbeat or tremors. Our Wechselwirkungs-Checker für Medikamente helps you check whether dein prescriptions, over-the-counter medicines, and supplements are safe to.
Patient information leaflet
Kann ich Adcal-D3 und Omega-3 zusammen einnehmen?
Es gibt no known harmful interaction between Adcal-D3 and Omega-3 (fish oil) supplements. In fact, taking them together may be slightly beneficial for bone health. Why this happens Adcal-D3 contains calcium and vitamin D3. Omega-3 fatty acids do not interfere with how the body absorbs or processes calcium or vitamin D. Some studies suggest that.
Patient information leaflet
Kann ich Bisoprolol und Trimbow zusammen einnehmen?
Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Why this happens Bisoprolol ist a 'beta-blocker' and formoterol (in Trimbow) is a 'beta-agonist'. Important precautions Acute breathing distress Bisoprolol ist a beta-blocker and can cause narrowing of the airways, potentially triggering a severe asthma attack.
Patient information leaflet
Kann ich Allopurinol und Co-amoxiclav zusammen einnehmen?
Taking allopurinol and co-amoxiclav together increases the risk of developing a skin rash. While most rashes are mild, there is a small risk of a more serious allerg... Penicillin allergy Do not take co-amoxiclav if you have ever had a severe allergic reaction (such as Anaphylaxie or a skin rash) zur Penicillin or any other 'beta-lactam'.
Patient information leaflet
Kann ich Bisoprolol und Metformin zusammen einnehmen?
Bisoprolol can hide the warning signs of low blood sugar (hypoglycaemia). It may also slightly change how your body manages blood sugar levels, potentially making metformin less effective or increasing the risk of a 'hypo'. Why this happens Bisoprolol ist a beta-blocker. It works by slowing the heart rate and blocking certain stress hormones. These.
Weiterführende Lektüre und Referenzen
- laminin subunit beta 3; MedlinePlus, National Library of Medicine.
- Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JC, Kleinman HK, Marinkovich MP, Martin GR, Mayer U, Meneguzzi G, Miner JH, Miyazaki K, Patarroyo M, Paulsson M, Quaranta V, Sanes JR, Sasaki T, Sekiguchi K, Sorokin LM, Talts JF, Tryggvason K, Uitto J, Virtanen I, von der Mark K, Wewer UM, Yamada Y, Yurchenco PD. A simplified laminin nomenclature. Matrix Biol. 2005 Aug;24(5):326-32. doi: 10.1016/j.matbio.2005.05.006.
- Hartwig B, Borm B, Schneider H, Arin MJ, Kirfel G, Herzog V. Laminin-5-deficient human keratinocytes: defective adhesion results in a saltatory and inefficient mode of migration. Exp Cell Res. 2007 May 1;313(8):1575-87. doi: 10.1016/j.yexcr.2007.02.003. Epub 2007 Feb 9.
- Muhle C, Jiang QJ, Charlesworth A, Bruckner-Tuderman L, Meneguzzi G, Schneider H. Novel and recurrent mutations in the laminin-5 genes causing lethal junctional epidermolysis bullosa: molecular basis and clinical course of Herlitz disease. Hum Genet. 2005 Jan;116(1-2):33-42. doi: 10.1007/s00439-004-1210-y. Epub 2004 Nov 5.
- Nakano A, Chao SC, Pulkkinen L, Murrell D, Bruckner-Tuderman L, Pfendner E, Uitto J. Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes. Hum Genet. 2002 Jan;110(1):41-51. doi: 10.1007/s00439-001-0630-1. Epub 2001 Nov 13.
- Nakano A, Pfendner E, Hashimoto I, Uitto J. Herlitz junctional epidermolysis bullosa: novel and recurrent mutations in the LAMB3 gene and the population carrier frequency. J Invest Dermatol. 2000 Sep;115(3):493-8. doi: 10.1046/j.1523-1747.2000.00086.x.
- Pulkkinen L, Gerecke DR, Christiano AM, Wagman DW, Burgeson RE, Uitto J. Cloning of the beta 3 chain gene (LAMB3) of human laminin 5, a candidate gene in junctional epidermolysis bullosa. Genomics. 1995 Jan 1;25(1):192-8. doi: 10.1016/0888-7543(95)80125-6.
- Pulkkinen L, Uitto J. Mutation analysis and molecular genetics of epidermolysis bullosa. Matrix Biol. 1999 Feb;18(1):29-42. doi: 10.1016/s0945-053x(98)00005-5.
- Schneider H, Muhle C, Pacho F. Biological function of laminin-5 and pathogenic impact of its deficiency. Eur J Cell Biol. 2007 Dec;86(11-12):701-17. doi: 10.1016/j.ejcb.2006.07.004. Epub 2006 Sep 26.
- Varki R, Sadowski S, Pfendner E, Uitto J. Epidermolysis bullosa. I. Molecular genetics of the junctional and hemidesmosomal variants. J Med Genet. 2006 Aug;43(8):641-52. doi: 10.1136/jmg.2005.039685. Epub 2006 Feb 10.
Artikelverlauf
Artikel auch verfügbar in Englisch, Deutsch, Spanisch, Französisch, Italienisch, Portugiesisch, Hindi, Hebräisch, Arabisch, und Schwedisch.
3 Apr 2025 | Neueste Version
1 Sept 2009 | Ursprünglich veröffentlicht
Nehmen Sie an der Diskussion teil
Teilen Sie Ihre Gedanken oder Erfahrungen mit anderen in unserem Patientengemeinschaften.
Fragen, teilen, verbinden.
Durchsuchen Sie Diskussionen, stellen Sie Fragen und teilen Sie Erfahrungen zu Hunderten von Gesundheitsthemen.
Abonnieren Sie den Patienten-Newsletter
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsberatung - geschrieben, um Ihnen zu helfen, sich informiert, selbstbewusst und in Kontrolle zu fühlen.
Durch das Abonnieren akzeptieren Sie unsere Datenschutzrichtlinie. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals.