Can I take Esomeprazole and Trazodone together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Esomeprazole may reduce the amount of trazodone that your body absorbs. This could potentially make trazodone less effective at treating your symptoms (such as depression or sleep issues). Additionally, both medications can rarely affect the electrical activity of your heart, though this risk is generally low.
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Why this happens
Esomeprazole reduces stomach acid. Trazodone needs an acidic environment to dissolve properly so it can be absorbed into the bloodstream. Lower acid levels mean less medicine gets into your system. There is also a theoretical risk of 'QT prolongation' (a change in heart rhythm) when these types of drugs are used together.
What you should do
Back to contentsYou can generally take these together, but monitor your mood or sleep patterns closely. If you feel your trazodone is not working as well as it used to, or if you experience any unusual heart palpitations or dizziness, speak with your doctor. They may need to adjust your dose or the timing of when you take your tablets.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Can I take Acetaminophen and Trazodone together?
Taking paracetamol (acetaminophen) and trazodone together is generally considered safe, but there is a small risk of increased side effects. Both substances are processed by the liver, and in some cases, taking them together might slightly increase the levels of trazodone in your blood. This could make you feel more drowsy or dizzy than usual. Additionally, both medications can occasionally affect your liver function, so using them together over a long period requires caution.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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