Can I take Lercanidipine and Pregabalin together?

Why this happens

Lercanidipine works by relaxing blood vessels, which can sometimes cause fluid to leak into the tissues (swelling). Pregabalin affects the central nervous system and can also cause fluid retention and drowsiness. When used together, their similar side-effect profiles can have an additive effect on your body.

It is generally safe to take these together, but you should be aware of increased side effects. To stay safe, get up slowly from a sitting or lying position to avoid dizziness. If you notice significant swelling in your ankles, or if the drowsiness interferes with your daily activities (like driving), speak to your GP. Do not stop taking either medication without medical advice.

Mental health disorders

Pregabalin can cause suicidal thoughts or an urge to self-harm. You must seek medical help immediately if your mood changes or you have thoughts of hurting yourself.

Pregnancy

Pregabalin must not be used during pregnancy unless specifically advised by a specialist, as it may increase the risk of birth defects. Effective contraception must be used during treatment.

Severe respiratory issues or opioid use

Pregabalin can cause serious, life-threatening breathing problems, especially if you already have lung disease or if you take it alongside opioid painkillers or other sedatives.

History of drug or alcohol misuse

Pregabalin carries a high risk of dependence and addiction. It is a controlled drug because it can be misused, particularly if you have a history of substance abuse.

Severe liver or kidney disease

Lercanidipine is not recommended if you have severe liver or kidney problems. Ensure your doctor is aware of your condition before starting treatment.

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. For lercanidipine, alcohol can increase the blood-pressure-lowering effect, making you feel dizzy or faint. For pregabalin, alcohol increases the risk of severe drowsiness, dizziness, and breathing problems. Combining alcohol with these medicines increases the risk of accidents and liver strain.

Grapefruit and grapefruit juice

You must not eat grapefruit or drink grapefruit juice while taking lercanidipine. Grapefruit can significantly increase the amount of the medicine in your blood, making side effects like dizziness, headaches, and a fast heartbeat much more likely.

High-fat meals

Lercanidipine should be taken at least 15 minutes before a meal. Taking it with or immediately after a high-fat meal can significantly increase the amount of medicine absorbed by your body, which may lead to more side effects.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.