Can I take Lixiana and Morphine together?

Why this happens

Morphine slows down the movement of the digestive system (gastric emptying). This can delay how quickly Lixiana enters your bloodstream. Additionally, strong painkillers like morphine can sometimes mask the pain of internal bleeding or, in some cases, increase the risk of stomach irritation which may lead to bleeding when combined with a blood thinner.

What you should do

You can take these medicines together, but you should be extra vigilant. Watch for signs of unusual bleeding, such as bruising easily, nosebleeds, bleeding gums, or dark, tarry stools. If you are prescribed morphine for long-term use, discuss this with your doctor to ensure your dose of Lixiana is still providing the right level of protection. Always take your Lixiana exactly as prescribed.

Important precautions

Respiratory depression and sedation

Morphine can dangerously slow your breathing and cause extreme sleepiness. This risk is significantly increased if you drink alcohol or take other sedating medicines like benzodiazepines.

Drug dependence and addiction

Morphine is an opioid that carries a high risk of addiction and dependence, even at prescribed doses. Do not increase your dose without medical advice, and do not stop taking it suddenly.

Bleeding risk

Lixiana increases your risk of serious bleeding. Seek immediate medical help if you have a fall or head injury, or if you notice signs of internal bleeding such as black tarry stools, blood in your urine, or coughing up blood.

Surgery or dental procedures

You must tell your doctor or dentist you are taking Lixiana before any procedure, as you may need to stop taking it temporarily to prevent dangerous bleeding.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking morphine. Combining alcohol with morphine significantly increases the risk of dangerous side effects, such as extreme sleepiness, breathing difficulties, and a potentially fatal overdose.

It is best to avoid or strictly limit alcohol while taking Lixiana. Alcohol can increase the risk of bleeding in your stomach and intestines. Additionally, heavy drinking can affect how your liver functions, which may interfere with how your body processes this medication.

Grapefruit juice

Avoid drinking large amounts of grapefruit juice. It can increase the levels of morphine in your blood, making side effects like drowsiness or breathing problems more likely.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.