Can I take Losartan and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
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Both medications can cause drowsiness, dizziness, and a drop in blood pressure. Taking them together may increase the risk of feeling lightheaded, sleepy, or unsteady on your feet, which could lead to falls. Some patients may also experience increased swelling (fluid retention) in the legs or feet.
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Why this happens
This is a 'pharmacodynamic' interaction, meaning the drugs have different ways of working but produce similar side effects. Losartan lowers blood pressure, while pregabalin can cause dizziness and sedation as it affects the nervous system. When combined, these effects can add up. Additionally, both drugs are occasionally linked to peripheral oedema (fluid swelling).
What you should do
It is generally safe to take these together, but you should be cautious, especially when starting the combination or increasing the dose. Avoid driving or operating machinery until you know how the mix affects you. To prevent dizziness, try to stand up slowly from a sitting or lying position. If you notice significant swelling in your ankles or feel unusually faint, contact your doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
25 Jan 2026 | Ursprünglich veröffentlicht

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