Can I take Pregabalin and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking pregabalin and sertraline together can increase the risk of side effects that affect your brain and nervous system. You may feel more drowsy, dizzy, or confused than usual. It can also make it harder to concentrate or perform tasks that require alertness, such as driving. In some cases, especially in older adults, it may increase the risk of falls.
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Why this happens
Both medicines have a 'depressant' effect on the central nervous system. While they work in different ways, their sedative effects add together (an additive effect), making the overall impact on your coordination and alertness stronger than if you took either medicine alone.
What you should do
You can take these medicines together if your doctor has prescribed them, but you should be cautious. Monitor how you feel, especially when starting the combination or changing the dose. Avoid driving or operating machinery until you know how this combination affects you. Limit or avoid alcohol, as it will make these side effects much worse. If you feel extremely sleepy or unsteady on your feet, contact your doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Haftungsausschluss
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Artikel Geschichte
Die Informationen auf dieser Seite wurden von qualifizierten Klinikern verfasst und von Fachleuten geprüft.
25 Jan 2026 | Ursprünglich veröffentlicht

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