Laing distal myopathy
Zuletzt aktualisiert 18. Aug 2020
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Laing distal myopathy is a condition that affects skeletal muscles, which are muscles that the body uses for movement. This disorder causes progressive muscle weakness that appears in childhood. The first sign of Laing distal myopathy is usually weakness in certain muscles in the feet and ankles. This weakness leads to tightening of the Achilles tendon (the band that connects the heel of the foot to the calf muscles), an inability to lift the first (big) toe, and a high-stepping walk. Months to years later, muscle weakness develops in the hands and wrists. Weakness in these muscles makes it difficult to lift the fingers, particularly the third and fourth fingers. Many affected people also experience hand tremors.
Beschreibung
Laing distal myopathy is a condition that affects skeletal muscles, which are muscles that the body uses for movement. This disorder causes progressive muscle weakness that appears in childhood. The first sign of Laing distal myopathy is usually weakness in certain muscles in the feet and ankles. This weakness leads to tightening of the Achilles tendon (the band that connects the heel of the foot to the calf muscles), an inability to lift the first (big) toe, and a high-stepping walk. Months to years later, muscle weakness develops in the hands and wrists. Weakness in these muscles makes it difficult to lift the fingers, particularly the third and fourth fingers. Many affected people also experience hand tremors.
In addition to muscle weakness in the hands and feet, Laing distal myopathy causes weakness in several muscles of the neck and face. A decade or more after the onset of symptoms, mild weakness also spreads to muscles in the legs, hips, and shoulders. Laing distal myopathy progresses very gradually, and most affected people remain mobile throughout life. Life expectancy is normal in people with this condition.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
Distal myopathy 1
Laing early-onset distal myopathy
MPD1
Related patient information and medicines
Patient information leaflet
Muskeldystrophie
Muskeldystrophie ist ein vererbte (genetic) disorder causing muscle weakness. There are different types of muscular dystrophy, which vary as to how severe they are, ranging from very mild to severe. The different types also vary as to what age they begin. ... There are other medical conditions which cause muscle weakness. These are: Conditions.
Patient information leaflet
Kann ich Atorvastatin und Mariendistelextrakt zusammen einnehmen?
Taking milk thistle with atorvastatin might increase the levels of the medication in your bloodstream. This could potentially increase the risk of side effects, such as muscle aches, pain, or weakness (a condition called myopathy). Caution is advised when taking atorvastati and milk thistle together. Combining them may increase the amount of.
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Buerger-Krankheit
This can help to stop the disease from becoming worse and reduces your chance of needing surgical removal (amputation) of a finger, a toe, or worse. What is Buerger's disease. Buerger-Krankheit ist a condition that causes inflammation of the small- and medium-sized blood vessels in legs and arms, particularly those in the hands and feet. It is.
Patient information leaflet
Refeeding-Syndrom
Refeeding-Syndrom was first described in Far East prisoners after the second world war when they developed Herzversagen after starting to eat again after a prolonged period of starvation. What is refeeding syndrome. Refeeding-Syndrom ist a dangerous and life threatening shift of fluids and body salts (electrolytes) that can occur when.
Patient information leaflet
Kann ich Amlodipin und Atorvastatin zusammen einnehmen?
Taking amlodipine and atorvastatin together can increase the amount of atorvastatin in your blood. This may increase the risk of side effects, particularly muscle pain, tenderness, or weakness (a condition called myopathy). In rare cases, this can lead to a more serious muscle breakdown called rhabdomyolysis. Amlodipine and atorvastatin can.
Patient information leaflet
Kann ich Atorvastatin und Pyridostigmin zusammen einnehmen?
There is a potential for increased muscle-related side effects when taking these two medicines together. Both drugs can independently affect muscle function; atorvastatin can cause muscle aches or weakness (myopathy), und pyridostigmine is used to treat Muskelschwäche in conditions like myasthenia gravis. Taking them together might make it harder.
Weiterführende Lektüre und Referenzen
- Laing distal myopathy; MedlinePlus, National Library of Medicine.
- Laing NG, Laing BA, Meredith C, Wilton SD, Robbins P, Honeyman K, Dorosz S, Kozman H, Mastaglia FL, Kakulas BA. Autosomal dominant distal myopathy: linkage to chromosome 14. Am J Hum Genet. 1995 Feb;56(2):422-7.
- Lamont P, Laing NG. Laing Distal Myopathy. 2006 Oct 17 [updated 2021 Feb 4]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1433/
- Lamont P, Wallefeld W, Davis M, Udd B, Laing N. Clinical utility gene card for: Laing distal myopathy. Eur J Hum Genet. 2011 Mar;19(3). doi: 10.1038/ejhg.2010.190. Epub 2010 Dec 8. No abstract available.
- Lamont PJ, Udd B, Mastaglia FL, de Visser M, Hedera P, Voit T, Bridges LR, Fabian V, Rozemuller A, Laing NG. Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy. J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):208-15. doi: 10.1136/jnnp.2005.073825. Epub 2005 Aug 15.
- Meredith C, Herrmann R, Parry C, Liyanage K, Dye DE, Durling HJ, Duff RM, Beckman K, de Visser M, van der Graaff MM, Hedera P, Fink JK, Petty EM, Lamont P, Fabian V, Bridges L, Voit T, Mastaglia FL, Laing NG. Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1). Am J Hum Genet. 2004 Oct;75(4):703-8. doi: 10.1086/424760. Epub 2004 Aug 20.
- Udd B. Distal muscular dystrophies. Handb Clin Neurol. 2011;101:239-62. doi: 10.1016/B978-0-08-045031-5.00016-5.
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18. Aug 2020 | Neueste Version
1 Aug 2008 | Ursprünglich veröffentlicht
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