potassium inwardly rectifying channel subfamily J member 1
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Der KCNJ1 gene belongs to a large family of genes that produce potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
Normal function
Der KCNJ1 gene belongs to a large family of genes that produce potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
The specific function of a potassium channel depends on its protein components and its location in the body. Channels made with the KCNJ1 protein, also known as ROMK, are predominantly found in the kidneys. ROMK is one of several proteins that work together to regulate the movement of ions into and out of kidney cells. In particular, the transport of potassium ions by ROMK is necessary for the normal function of another ion transporter called NKCC2 (which is produced from the SLC12A1 gene). This transporter plays an essential role in the reabsorption of salt (sodium chloride or NaCl) from the urine back into the bloodstream. The retention of salt affects the body's fluid levels and helps maintain blood pressure.
Conditions referring to this gene or chromosome
Other names
ATP-regulated potassium channel ROM-K
ATP-sensitive inward rectifier potassium channel 1
inward rectifier K(+) channel Kir1.1
inwardly rectifying K+ channel
IRK1_HUMAN
KIR1.1
potassium channel, inwardly rectifying subfamily J member 1
potassium channel, inwardly rectifying subfamily J, member 1
potassium inwardly-rectifying channel, subfamily J, member 1
ROMK
ROMK1
Related patient information and medicines
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Akutes Nierenversagen
Akutes Nierenversagen can be a confusing name as it suggests an accident or injury to that part of your body, eg from a fall or trauma. If you are not in hospital already, you will be sent to hospital to be looked after. Higher levels mean that the kidneys aren't getting rid of waste produc... There will often be raised potassium (one of the salts.
Patient information leaflet
Kann ich Bisoprolol und Ramipril zusammen einnehmen?
This might make you feel dizzy, lightheaded, or faint. It can also occasionally lead to increased levels of potassium in your blood oder affect how your kidneys work. Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while ramipril is an ACE inhibitor that.
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Kann ich Atenolol und Ramipril zusammen einnehmen?
It is best to keep your alcohol intake within recommended limits and see how the medicine affects you before drinking. Salt substitutes (Potassium-rich) Ramipril can increase the levels of potassium in dein blood. Many salt substitutes (such as Lo-Salt) contain potassium chloride instead of sodium. Haftungsausschluss This information is for general.
Patient information leaflet
Kann ich Co-amoxiclav und Ramipril zusammen einnehmen?
Taking co-amoxiclav und ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood oder affect your kidney function, especially if you are already unwell with an infection. Why this happens Both drugs can.
Patient information leaflet
Kann ich Bisoprolol und Losartan zusammen einnehmen?
Nehmen bisoprolol and losartan together can cause your blood pressure to drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when standing up quickly. Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while Losartan is an.
Patient information leaflet
Angina
Angina is a pain that comes from the heart. It is usually caused by narrowing of the heart's blood vessels - the (coronary) arteries. Usual treatment includes a statin medicine to lower your cholesterol level, low-dose aspirin to help prevent a heart attack, and a beta-blocker medicine to help protect the heart and to prevent angina pains. An.
Weiterführende Lektüre und Referenzen
- potassium inwardly rectifying channel subfamily J member 1; MedlinePlus, National Library of Medicine.
- Derst C, Konrad M, Kockerling A, Karolyi L, Deschenes G, Daut J, Karschin A, Seyberth HW. Mutations in the ROMK gene in antenatal Bartter syndrome are associated with impaired K+ channel function. Biochem Biophys Res Commun. 1997 Jan 23;230(3):641-5. doi: 10.1006/bbrc.1996.6024.
- Jeck N, Derst C, Wischmeyer E, Ott H, Weber S, Rudin C, Seyberth HW, Daut J, Karschin A, Konrad M. Functional heterogeneity of ROMK mutations linked to hyperprostaglandin E syndrome. Kidney Int. 2001 May;59(5):1803-11. doi: 10.1046/j.1523-1755.2001.0590051803.x.
- Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet. 2008 May;40(5):592-599. doi: 10.1038/ng.118. Epub 2008 Apr 6.
- Peters M, Ermert S, Jeck N, Derst C, Pechmann U, Weber S, Schlingmann KP, Seyberth HW, Waldegger S, Konrad M. Classification and rescue of ROMK mutations underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome. Kidney Int. 2003 Sep;64(3):923-32. doi: 10.1046/j.1523-1755.2003.00153.x.
- Simon DB, Karet FE, Rodriguez-Soriano J, Hamdan JH, DiPietro A, Trachtman H, Sanjad SA, Lifton RP. Genetic heterogeneity of Bartter's syndrome revealed by mutations in the K+ channel, ROMK. Nat Genet. 1996 Oct;14(2):152-6. doi: 10.1038/ng1096-152.
- Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR, Samani NJ. Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. Hypertension. 2008 Jun;51(6):1658-64. doi: 10.1161/HYPERTENSIONAHA.108.112664. Epub 2008 Apr 28.
- Welling PA, Ho K. A comprehensive guide to the ROMK potassium channel: form and function in health and disease. Am J Physiol Renal Physiol. 2009 Oct;297(4):F849-63. doi: 10.1152/ajprenal.00181.2009. Epub 2009 May 20.
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12. Apr 2023 | Neueste Version
1 Feb 2011 | Ursprünglich veröffentlicht
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