APC regulator of Wnt signaling pathway
Zuletzt aktualisiert 26. Aug 2025
Erfüllt die redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen
- Language
- Diskussion
- Audio-Version
- Zu bevorzugten Quellen bei Google hinzufügen
The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts as a tumour suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. This protein blocks a chemical signaling pathway known as Wnt signaling. This pathway promotes cell growth and division (proliferation) and controls the activity (expression) of certain genes.
Normal function
The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts as a tumour suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. This protein blocks a chemical signaling pathway known as Wnt signaling. This pathway promotes cell growth and division (proliferation) and controls the activity (expression) of certain genes.
The APC protein attaches (binds) to multiple proteins to form a complex that helps to control levels of another protein called beta-catenin. Beta-catenin is a key part of the Wnt pathway, and it helps control many cell functions, including cell proliferation, gene expression, and the process by which cells mature to carry out specific functions (differentiation). When the APC protein complex binds beta-catenin, it helps break the protein down when it is no longer needed.
The APC protein also plays a role in regulating cell division. The protein interacts with parts of the cell's structural framework (cytoskeleton) to help with proper cell organisation during cell division. This helps ensure that the number of chromosomes in a cell is correct after the cell divides.
Conditions referring to this gene or chromosome
Other names
adenomatous polyposis coli
APC_HUMAN
WNT signaling pathway regulator
Related patient information and medicines
Patient information leaflet
Kann ich Apixaban und Empagliflozin zusammen einnehmen?
... It is generally considered safe to take these two medications together. Why this happens Apixaban (a blood thinner) and empagliflozin (a diabetes medication) are processed by different pathways in the body. Apixaban is mainly broken down by specific liver enzymes (CYP3A4) and a transport protein (P-gp), while empagliflozin is processed through.
Patient information leaflet
Nervenleitungsstudien
Nervenleitungsstudien help to test how well and how fast nerves conduct electrical signals. Note : the information below is a general guide only. The arrangements, and the way tests are performed, may vary between different hospitals. Always follow the instructions given by your doctor or local hospital. What are nerve conduction studies. Nerve.
Patient information leaflet
Astigmatismus
Astigmatism is a common eye condition das affects Arztpraxis shape of the cornea oder Arztpraxis lens of the eye. The cornea and lens are typically smooth and round in shape, but in people with astigmatism, they are irregularly shaped. The main symptom of astigmatism is blurred vision. It occurs because the cornea at the front of the eye is unevenly curved..
Patient information leaflet
Kann ich Atorvastatin und Empagliflozin zusammen einnehmen?
There are no known significant inter... These two medicines are frequently prescribed together to manage heart health and blood sugar levels. Why this happens Atorvastatin and empagliflozin are processed by different pathways in the body. Atorvastatin is primarily broken down by the liver (CYP3A4 enzyme), while empagliflozin is processed through a.
Patient information leaflet
Kann ich Apixaban und Losartan zusammen einnehmen?
They are often prescribed togeth... However, both medications can affect your kidneys or blood pressure, so your doctor will likely monitor your kidney function and blood pressure regularly. Why this happens Apixaban ist an anticoagulant (blood thinner) and losartan ist an Angiotensin II Receptor Blocker (blood pressure medication). They are.
Patient information leaflet
Kann ich Biotin und Isosorbidmononitrat zusammen einnehmen?
There is no known interaction between biotin and isosorbide mononitrate (also known by brand names like Carmil or Monomil). Biotin is a B-vitamin, and isosorbide mononitrate is a nitrate medication used to prevent chest pain (angina). They work in completely different ways in the body and do not interfere with each other's absorption or.
Weiterführende Lektüre und Referenzen
- APC regulator of Wnt signaling pathway; MedlinePlus, National Library of Medicine.
- Abbott J, Nathke IS. The adenomatous polyposis coli protein 30 years on. Semin Cell Dev Biol. 2023 Dec;150-151:28-34. doi: 10.1016/j.semcdb.2023.04.004. Epub 2023 Apr 22.
- Ditonno I, Novielli D, Celiberto F, Rizzi S, Rendina M, Ierardi E, Di Leo A, Losurdo G. Molecular Pathways of Carcinogenesis in Familial Adenomatous Polyposis. Int J Mol Sci. 2023 Mar 16;24(6):5687. doi: 10.3390/ijms24065687.
- Jaiswal AS, Balusu R, Narayan S. Involvement of adenomatous polyposis coli in colorectal tumorigenesis. Front Biosci. 2005 May 1;10:1118-34. doi: 10.2741/1605.
- Joo JE, Viana-Errasti J, Buchanan DD, Valle L. Genetics, genomics and clinical features of adenomatous polyposis. Fam Cancer. 2025 Apr 16;24(2):38. doi: 10.1007/s10689-025-00460-0.
- Lips DJ, Barker N, Clevers H, Hennipman A. The role of APC and beta-catenin in the aetiology of aggressive fibromatosis (desmoid tumors). Eur J Surg Oncol. 2009 Jan;35(1):3-10. doi: 10.1016/j.ejso.2008.07.003. Epub 2008 Aug 21.
- Sena P, Saviano M, Monni S, Losi L, Roncucci L, Marzona L, De Pol A. Subcellular localization of beta-catenin and APC proteins in colorectal preneoplastic and neoplastic lesions. Cancer Lett. 2006 Sep 28;241(2):203-12. doi: 10.1016/j.canlet.2005.10.011. Epub 2005 Nov 17.
- Senda T, Shimomura A, Iizuka-Kogo A. Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. Anat Sci Int. 2005 Sep;80(3):121-31. doi: 10.1111/j.1447-073x.2005.00106.x.
- Tejpar S, Michils G, Denys H, Van Dam K, Nik SA, Jadidizadeh A, Cassiman JJ. Analysis of Wnt/Beta catenin signalling in desmoid tumors. Acta Gastroenterol Belg. 2005 Jan-Mar;68(1):5-9.
- Yang W, Ding PR. Update on Familial Adenomatous Polyposis-Associated Desmoid Tumors. Clin Colon Rectal Surg. 2023 Apr 17;36(6):400-405. doi: 10.1055/s-0043-1767709. eCollection 2023 Nov.
- Yen T, Stanich PP, Axell L, Patel SG. APC-Associated Polyposis Conditions. 1998 Dec 18 [updated 2022 May 12]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1345/
Artikelverlauf
Artikel auch verfügbar in Englisch, Deutsch, Spanisch, Französisch, Italienisch, Portugiesisch, Hindi, Hebräisch, Arabisch, und Schwedisch.
26. Aug 2025 | Neueste Version
1 Aug 2025 | Ursprünglich veröffentlicht
Nehmen Sie an der Diskussion teil
Teilen Sie Ihre Gedanken oder Erfahrungen mit anderen in unserem Patientengemeinschaften.
Fragen, teilen, verbinden.
Durchsuchen Sie Diskussionen, stellen Sie Fragen und teilen Sie Erfahrungen zu Hunderten von Gesundheitsthemen.
Abonnieren Sie den Patienten-Newsletter
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsberatung - geschrieben, um Ihnen zu helfen, sich informiert, selbstbewusst und in Kontrolle zu fühlen.
Durch das Abonnieren akzeptieren Sie unsere Datenschutzrichtlinie. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals.