sodium voltage-gated channel alpha subunit 2
Zuletzt aktualisiert 1. Jul 2025
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The SCN2A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged atoms (ions) of sodium into cells, play a key role in a cell's ability to generate and transmit electrical signals.
Normal function
The SCN2A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged atoms (ions) of sodium into cells, play a key role in a cell's ability to generate and transmit electrical signals.
The SCN2A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.2. These channels are primarily found in the brain, where they control the flow of sodium ions into nerve cells (neurons). NaV1.2 channels are involved in transmitting signals from one neuron to another. Communication between neurons depends on chemicals called neurotransmitters, which are released from one neuron and taken up by neighboring neurons. The flow of sodium ions through NaV1.2 channels helps determine when neurotransmitters will be released.
Conditions referring to this gene or chromosome
Other names
NAC2
NAV1.2
SCN2A1
SCN2A2
sodium channel, brain type II, alpha subunit
sodium channel, voltage gated, type II alpha subunit
sodium channel, voltage-gated, type II, alpha 1 polypeptide
sodium channel, voltage-gated, type II, alpha 2 polypeptide
sodium channel, voltage-gated, type II, alpha subunit
sodium voltage-gated channel, alpha subunit 2
Related patient information and medicines
Patient information leaflet
Kaliumsparende Diuretika
Diuretika are medicines which increase the amount of fluid removed from the body when we pass urine. Potassium-sparing diuretics are one type of diuretic. They are weak diuretics usually prescribed in combination with other types of diuretics. They are used to increase the amount of fluid passed from the body in urine, whilst also preventing too.
Patient information leaflet
Kann ich Magnesium und Flecainid zusammen einnehmen?
In some cases, magnesium can actually be helpful for heart rhythm issues, but it must be balanced correctly. Why this happens Both magnesium and flecainide affect the electrical signals and mineral channels (like sodium and potassium) in your heart cells. While they don't usually stop each other from being absorbed, having too much or too little.
Patient information leaflet
Hoher Blutdruck
Bluthochdruck (Hypertonie) tritt auf, wenn der Druck auf die Wände der Blutgefäße (verursacht durch das Blut in ihnen) höher als normal ist. This means the heart has to work harder and the blood vessels are under more strain, making it a major risk factor for heart disease , stroke and other serious conditions. What is high blood pressure. High.
Patient information leaflet
Hyponatriämie
Hyponatraemia is a low level of sodium in the blood. Sodium levels in the blood have to be tightly controlled. Various chemical messengers (hormones) and organs are involved in this process. For example, hormones involved include antidiuretic hormone and cortisol, and organs involved include the brain and kidneys. There is a very close.
Patient information leaflet
Ernährung bei Typ-2-Diabetes
The first-line treatment for type 2 diabetes involves making Änderungen to your lifestyle, through diet, weight control and physical activity. Regular check-ups and medication for diabetes (whether in tablet or injection form) definitely aren't the only way to control your blood sugar (glucose) levels. In fact, there is evidence that many people who.
Patient information leaflet
Thalassämie
Thalassämie ist an inherited condition affecting the blood. There are different types, which vary from a mild condition to a serious or life-threatening condition. Thalassaemia is an inherited (genetic) condition affecting the blood. The cause is an inherited (genetic) change, involving the genes which tell the body how to make an important.
Weiterführende Lektüre und Referenzen
- sodium voltage-gated channel alpha subunit 2; MedlinePlus, National Library of Medicine.
- Howell KB, McMahon JM, Carvill GL, Tambunan D, Mackay MT, Rodriguez-Casero V, Webster R, Clark D, Freeman JL, Calvert S, Olson HE, Mandelstam S, Poduri A, Mefford HC, Harvey AS, Scheffer IE. SCN2A encephalopathy: A major cause of epilepsy of infancy with migrating focal seizures. Neurology. 2015 Sep 15;85(11):958-66. doi: 10.1212/WNL.0000000000001926. Epub 2015 Aug 19.
- Thompson CH, Potet F, Abramova TV, DeKeyser JM, Ghabra NF, Vanoye CG, Millichap JJ, George AL. Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties. J Gen Physiol. 2023 Oct 2;155(10):e202313375. doi: 10.1085/jgp.202313375. Epub 2023 Aug 14.
- Yang XR, Ginjupalli VKM, Theriault O, Poulin H, Appendino JP, Au PYB, Chahine M. SCN2A-related epilepsy of infancy with migrating focal seizures: report of a variant with apparent gain- and loss-of-function effects. J Neurophysiol. 2022 May 1;127(5):1388-1397. doi: 10.1152/jn.00309.2021. Epub 2022 Apr 13.
- Zeng Q, Yang Y, Duan J, Niu X, Chen Y, Wang D, Zhang J, Chen J, Yang X, Li J, Yang Z, Jiang Y, Liao J, Zhang Y. SCN2A-Related Epilepsy: The Phenotypic Spectrum, Treatment and Prognosis. Front Mol Neurosci. 2022 Mar 30;15:809951. doi: 10.3389/fnmol.2022.809951. eCollection 2022.
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1. Jul 2025 | Neueste Version
1. Jul 2025 | Ursprünglich veröffentlicht
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