prokineticin receptor 2
Zuletzt aktualisiert 19 Apr 2023
Erfüllt die redaktionelle Richtlinien
- HerunterladenHerunterladen
- Teilen
- Language
- Diskussion
- Audio-Version
- Zu bevorzugten Quellen bei Google hinzufügen
Der PROKR2 gene provides instructions for making a protein called prokineticin receptor 2. This receptor interacts with a protein called prokineticin 2 (produced from the PROK2 gene). On the cell surface, prokineticin 2 attaches to the receptor like a key in a lock. When the two proteins are connected, they trigger a series of chemical signals within the cell that regulate various cell functions. Prokineticin 2 and its receptor are produced in many organs and tissues, including the small intestine, certain regions of the brain, and several hormone-producing (endocrine) tissues.
Normal function
Der PROKR2 gene provides instructions for making a protein called prokineticin receptor 2. This receptor interacts with a protein called prokineticin 2 (produced from the PROK2 gene). On the cell surface, prokineticin 2 attaches to the receptor like a key in a lock. When the two proteins are connected, they trigger a series of chemical signals within the cell that regulate various cell functions. Prokineticin 2 and its receptor are produced in many organs and tissues, including the small intestine, certain regions of the brain, and several hormone-producing (endocrine) tissues.
Prokineticin 2 and its receptor play a role in the development of a group of nerve cells that are specialized to process smells (olfactory neurons). These neurons move (migrate) from the developing nose to a structure in the front of the brain called the olfactory bulb, which is critical for the perception of odors. Prokineticin 2 and its receptor are also involved in the migration of nerve cells that produce gonadotropin-releasing hormone (GnRH). GnRH controls the production of several hormones that direct sexual development before birth and during puberty. These hormones are also important for the normal function of the ovaries in women and the testes in men.
Several additional functions of prokineticin 2 and its receptor have been discovered. These proteins help stimulate the movement of food through the intestine and are likely involved in the formation of new blood vessels (angiogenesis). They also play a role in coordinating daily (circadian) rhythms, such as the sleep-wake cycle and regular changes in body temperature. Prokineticin 2 and its receptor are active in a region of the brain called the suprachiasmatic nucleus (SCN), which acts as an internal clock that controls circadian rhythms.
Conditions referring to this gene or chromosome
Other names
G protein-coupled receptor 73-like 1
GPR73b
GPR73L1
GPRg2
KAL3
PK-R2
PKR2
PKR2_HUMAN
Related patient information and medicines
Patient information leaflet
Orale Bronchodilatatoren
Orale Bronchodilatatoren are medicines that are sometimes used to treat breathing problems in people with asthma and other lung-related problems such as chronic obstructive pulmonary disease (COPD). They are not used very often, because inhaled bronchodilators usually wo... For example, cimetidine, ciprofloxacin, erythromycin, fluvoxamine, and St.
Patient information leaflet
Übelkeitsmedikament
Various medicines sind available to treat nausea. They work in different ways to one another. These medicines are not usually started until your doctor is sure what has caused your nausea. This is because knowing the cause helps your doctor to choose the right medicine for you. If they are required then any medicine usually only needs to be taken.
Patient information leaflet
Verlust von Geschmack und Geruch
Taste and smell sind often referred to as a pair because they are closely interlinked. The majority of what we think is our taste sensation is actually from our sense of smell. Rarely, some cancers c... What medicines can affect taste. Commonly prescribed antibiotics such as amoxicillin, erythromycin, ciprofloxacin and trimethoprim. Medicines used.
Patient information leaflet
Myasthenia gravis
Myasthenia gravis (MG) ist a condition where muscles become easily müde und weak. It is due to a problem with how the nerves stimulate the muscles to tighten (contract). The muscles around the eyes are commonly affected first. This causes drooping eyelids and double vision. Treatment is usually effective. However, relapses are common and many.
Patient information leaflet
Mastozytose und Mastzellenerkrankungen
Mast cells sind hard-working cells that have many functions, including helping to fight infection. However, mast cell disorders can occur in which too many cells are produced or they become overactive. What are the types of mast cell disorder. Mastocytosis This is the term used when too many mast cells are produced. There are many different types.
Patient information leaflet
Kann ich Codein und Morphin zusammen einnehmen?
Nehmen codeine and morphine together significantly increases Arztpraxis risk of serious side effects, including extreme sleepiness, dizziness, and dangerous breathing problems. Why this happens Both codeine and morphine work by attaching to the same receptors in the brain and spinal cord to block pain. ...riptions, over-the-counter medicines, and.
Weiterführende Lektüre und Referenzen
- prokineticin receptor 2; MedlinePlus, National Library of Medicine.
- Dode C, Rondard P. PROK2/PROKR2 Signaling and Kallmann Syndrome. Front Endocrinol (Lausanne). 2013 Apr 12;4:19. doi: 10.3389/fendo.2013.00019. eCollection 2013.
- Dode C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML, Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A, Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP. Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2. PLoS Genet. 2006 Oct 20;2(10):e175. doi: 10.1371/journal.pgen.0020175. Epub 2006 Sep 1.
- Matsumoto S, Yamazaki C, Masumoto KH, Nagano M, Naito M, Soga T, Hiyama H, Matsumoto M, Takasaki J, Kamohara M, Matsuo A, Ishii H, Kobori M, Katoh M, Matsushime H, Furuichi K, Shigeyoshi Y. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4140-5. doi: 10.1073/pnas.0508881103. Epub 2006 Mar 2.
- Moya-Plana A, Villanueva C, Laccourreye O, Bonfils P, de Roux N. PROKR2 and PROK2 mutations cause isolated congenital anosmia without gonadotropic deficiency. Eur J Endocrinol. 2012 Dec 10;168(1):31-7. doi: 10.1530/EJE-12-0578. Print 2013 Jan.
- Ng KL, Li JD, Cheng MY, Leslie FM, Lee AG, Zhou QY. Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. Science. 2005 Jun 24;308(5730):1923-7. doi: 10.1126/science.1112103.
- Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES. Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):648-53. doi: 10.1073/pnas.0606884104. Epub 2007 Jan 3.
- Sarfati J, Dode C, Young J. Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes: pathophysiology and genotype-phenotype correlations. Front Horm Res. 2010;39:121-132. doi: 10.1159/000312698. Epub 2010 Apr 8.
Artikelverlauf
Artikel auch verfügbar in Englisch, Deutsch, Spanisch, Französisch, Italienisch, Portugiesisch, Hindi, Hebräisch, Arabisch, und Schwedisch.
19 Apr 2023 | Neueste Version
1 Dec 2016 | Ursprünglich veröffentlicht
Nehmen Sie an der Diskussion teil
Teilen Sie Ihre Gedanken oder Erfahrungen mit anderen in unserem Patientengemeinschaften.
Fragen, teilen, verbinden.
Durchsuchen Sie Diskussionen, stellen Sie Fragen und teilen Sie Erfahrungen zu Hunderten von Gesundheitsthemen.
Abonnieren Sie den Patienten-Newsletter
Ihre wöchentliche Dosis klarer, vertrauenswürdiger Gesundheitsberatung - geschrieben, um Ihnen zu helfen, sich informiert, selbstbewusst und in Kontrolle zu fühlen.
Durch das Abonnieren akzeptieren Sie unsere Datenschutzrichtlinie. Sie können sich jederzeit abmelden. Wir verkaufen Ihre Daten niemals.