Darunavir for HIV

About darunavir

Darunavir is an antiretroviral medicine. It is prescribed for human immunodeficiency virus (HIV) infection. It slows the progress of HIV infection, but it is not a cure. HIV destroys cells in the body, called CD4 T cells. These cells are a type of white blood cell and are important because they are involved in protecting your body from infection. If left untreated, the HIV infection weakens your immune system so that your body cannot defend itself against bacteria, viruses and other germs. Darunavir slows down the progress of HIV infection by reducing the amount of virus in your body. It does this by stopping the production of a protein that the virus needs to copy (replicate) itself.

Darunavir will be prescribed for you by a doctor who is a specialist. It belongs to a group of antiretroviral medicines known as protease inhibitors (PIs). It is given alongside a number of other antiretroviral medicines, as part of a combination therapy. Taking three or more antiretroviral medicines at the same time is more effective than taking one alone. Taking a combination of different medicines also reduces the risk that the virus will become resistant to any individual medicine. One brand of darunavir called Rezolsta® also contains a medicine called cobicistat. Cobicistat boosts the effect of darunavir. Not all of the information in this document may apply to the combination brand - please refer to the manufacturer's printed information leaflet from inside the pack.

It is vital to take your antiretroviral medicines exactly as prescribed to maintain success and to help to prevent the virus from becoming resistant to the medicines. These medicines are usually taken for life.

Before taking darunavir

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking darunavir it is important that your doctor knows:

• Wenn Sie schwanger sind, ein Kind erwarten oder stillen.

• Wenn Sie Diabetes (Diabetes mellitus) haben.

• Wenn Sie eine Leberentzündung (Hepatitis genannt) oder ein anderes Leberproblem haben.

• Wenn Sie entweder an Hämophilie oder Porphyrie leiden, beides seltene vererbbare Blutkrankheiten.

• Wenn Sie andere Arzneimittel einnehmen. Dazu gehören alle Arzneimittel, die ohne Rezept erhältlich sind, sowie pflanzliche und ergänzende Arzneimittel.

• If you have ever had an allergic reaction to a medicine. This is particularly important if you know you are allergic to a medicine known as a sulfonamide.

How to take darunavir

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about darunavir, and it will also provide you with a full list of the side-effects which you could experience from taking it.

• Take darunavir exactly as your doctor tells you to. You will be asked to take either one or two doses daily, at the same time as a booster medicine (either ritonavir or cobicistat).

• There are several strengths of darunavir tablets available - your doctor will tell you which is right for you (or your child). It is important that you take darunavir at a mealtime (or within 30 minutes of eating a meal) as this will help your body to absorb the medicine.

• Try to take darunavir at the same time(s) of day each day, as this will help you to remember to take it regularly.

• If you forget to take your dose, take it with something to eat as soon as you remember unless:
  

  • You usually take darunavir twice a day and you are more than 6 hours late; in which case do not take the missed dose but do take your next dose when it is due.

  • You usually take darunavir once a day and you are more than 12 hours late; in which case do not take the missed dose but do take your next dose when it is due.

Instructions for using the dosing syringe with Prezista® Oral Suspension

1. Shake the bottle well.

2. Entfernen Sie den Flaschenverschluss.

3. Make sure the plunger of the syringe is pushed in fully, then insert the syringe into the bottle.

4. Gently pull out the plunger of the syringe so that the medicine fills the syringe to the mark which corresponds to your dose.

5. Put the tip of the syringe into your (or your child's) mouth, and gently push the plunger so that the medicine is released.

6. Replace the bottle cap. Wash the syringe with water after each use.

Das Beste aus Ihrer Behandlung herausholen

• Keep your regular appointments with your doctor so that your progress can be monitored. You will need to have regular blood tests while you are taking this medicine, to make sure your liver stays healthy.

• It is important that you continue to take darunavir and your other antiretroviral treatment regularly. This will help to prevent the HIV from becoming resistant to the medicines you are taking. Even if you miss only a small number of doses, the virus can become resistant to treatment.

• If you develop any infection soon after you start this treatment, let your doctor know. As a result of taking darunavir, your immune system may start fighting an infection which was present before you started the treatment, but which you may not have been aware of.

• Befolgen Sie sorgfältig alle Ratschläge Ihres Arztes, Ihre Lebensweise zu ändern, um das Risiko von Schäden an Ihrem Herz und Ihren Blutgefäßen zu verringern. Dazu kann gehören, mit dem Rauchen aufzuhören, sich gesund zu ernähren und regelmäßig Sport zu treiben.

• Bei manchen Menschen, die antiretrovirale Arzneimittel einnehmen, verändert sich die Verteilung des Körperfetts im Körper. Dies kann zu einer Veränderung des Körperbildes führen. Ihr Arzt wird mit Ihnen über die Möglichkeit einer solchen Veränderung sprechen.

• Die Behandlung mit antiretroviralen Medikamenten kann zwar das Risiko einer HIV-Übertragung durch sexuelle Kontakte verringern, aber nicht verhindern. Es ist wichtig, dass Sie Kondome benutzen.

• Being pregnant whilst taking darunavir can lead to lower blood levels of the medicine. This may mean your treatment becomes less effective than it should be. If you are pregnant, or planning to become pregnant, speak with your doctor for advice on alternative treatments.

• Es ist nicht ungewöhnlich, dass sich Menschen mit HIV niedergeschlagen oder sogar depressiv fühlen, vor allem kurz nachdem die Diagnose gestellt und die Behandlung begonnen wurde. Wenn Sie sich deprimiert fühlen oder beunruhigende Gedanken haben, sich selbst zu schaden, sollten Sie sofort mit Ihrem Arzt sprechen.

• Einige Menschen, die antiretrovirale Arzneimittel (insbesondere über einen langen Zeitraum) eingenommen haben, haben eine sogenannte Osteonekrose entwickelt. Dabei handelt es sich um eine Knochenkrankheit, bei der das Knochengewebe abstirbt, weil es nicht mehr ausreichend durchblutet wird. Dies führt zu Gelenkschmerzen und Steifheit und kann zu Bewegungseinschränkungen führen. Wenn Sie eines dieser Symptome bemerken, sollten Sie mit Ihrem Arzt sprechen.

• If you buy any medicines, check with a pharmacist that they are suitable to take with darunavir and your other medicines. This is because some medicines interfere with darunavir and either stop it from working properly or increase the risk of side-effects. In particular, do not take the herbal remedy St John's wort.

• Wenn Sie Diabetes haben, müssen Sie Ihren Blutzucker (Glukose) möglicherweise häufiger kontrollieren, da dieses Arzneimittel den Blutzuckerspiegel beeinflussen kann. Ihr Arzt wird Sie darüber informieren.

• Wenn Sie sich einer Operation oder einer zahnärztlichen Behandlung unterziehen müssen, teilen Sie der behandelnden Person mit, welche Arzneimittel Sie einnehmen.

• Treatment for HIV is usually lifelong. Continue to take darunavir regularly for as long as your doctor tells you to, even if you feel well. This is to keep your immune system healthy.

Can darunavir cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with darunavir. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Important: although it is common for people taking darunavir to develop a skin rash during the first few weeks of treatment, a severe rash with blisters may be a sign of a more serious allergic-type reaction. Let your doctor know straightaway if you develop the following:

• Severe blistering rash, high temperature, muscle and joint aches or pains, feeling generally unwell, mouth ulcers, and conjunctivitis.

Wenn Sie andere Symptome haben, von denen Sie glauben, dass sie auf das Arzneimittel zurückzuführen sind, sprechen Sie mit Ihrem Arzt oder Apotheker, um weiteren Rat zu erhalten.

How to store darunavir

• Bewahren Sie alle Arzneimittel außerhalb der Reichweite und Sichtweite von Kindern auf.

• An einem kühlen, trockenen Ort aufbewahren, vor direkter Hitze und Licht schützen.

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